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search_pharmgkb

Retrieve drug-gene interactions and pharmacogenomics data from PharmGKB by querying genes, drugs, or variants.

Instructions

Search PharmGKB for drug-gene interactions and pharmacogenomics data.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
queryYesGene name, drug name, or rsID
resource_typeNoType of resource: 'gene', 'drug', 'variant', or 'all' (default: 'all')all
Behavior2/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

No annotations provided. Description implies a read-only search but provides no details on behavior, such as whether it returns a list of results, pagination, rate limits, or any side effects. Bare minimum.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness4/5

Is the description appropriately sized, front-loaded, and free of redundancy?

Single sentence efficiently conveys the purpose. Could be slightly expanded to include expected output format, but overall concise.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness3/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

With only one sentence and no output schema, the description is minimal. It covers the basic purpose but lacks sufficient details about return values or result structure for an agent to fully anticipate outcomes.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Input schema has 100% coverage with adequate descriptions for both parameters. The description adds context about the type of data being searched but does not enhance understanding beyond what the schema already provides.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

Clearly states the tool searches PharmGKB for drug-gene interactions and pharmacogenomics data. The verb 'search' and resource 'PharmGKB' are specific, and it distinguishes from sibling search tools (e.g., search_clinvar, search_ensembl_gene).

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines2/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

No guidance on when to use this tool versus alternatives. Does not mention prerequisites, limitations, or situations where another tool would be more appropriate.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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