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get_clinvar_variant

Retrieve detailed ClinVar annotations and clinical significance for a genetic variant by providing its rsID or ClinVar ID.

Instructions

Get detailed ClinVar information for a specific variant by rsID or ClinVar ID.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
variant_idYesVariant identifier - rsID (e.g., 'rs80357906') or ClinVar ID
Behavior2/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

No annotations are provided, and the description does not disclose behavioral traits such as read-only nature, required permissions, or any side effects. As a query tool, it is assumed non-destructive, but no explicit confirmation is given.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is a single, clear sentence with no extraneous information. It is efficient and front-loaded with the key action and input type.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness3/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

For a simple tool with one parameter and no output schema, the description is minimal but adequate. However, it does not specify what 'detailed ClinVar information' includes, which could leave the agent uncertain about the output structure. Additional context about return format would improve completeness.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

The input schema has 100% description coverage for the single required parameter 'variant_id'. The schema already provides an example and explanation of acceptable values. The tool description adds no additional parameter semantics beyond the schema.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

Description clearly states the tool retrieves detailed ClinVar information for a specific variant by rsID or ClinVar ID, using a specific verb-resource structure. This distinguishes it from sibling tools like search_clinvar (which searches) and get_variant_info (which may be more general).

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines2/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

No guidance is provided on when to use this tool versus alternatives like search_clinvar or get_variant_info. The description does not specify any prerequisites or context for appropriate usage.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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