Bioinformatics
Tools for computational analysis of biological data, including genomics, proteomics, and other molecular biology data. Enables access to bioinformatics pipelines, algorithms, and databases.
MCP ServersBrowse all →
- AlicenseAqualityDmaintenanceEnables AI-driven pharmacogenomic analysis by querying structured genetic variant, drug response, and disease risk data. Supports natural language questions about medications, traits, and health risks based on user genome data, with privacy-first local execution.1645511MIT

reactome-mcpofficial
AlicenseBqualityFmaintenanceEnables AI assistants to search, browse, analyze, and export biological pathway data from Reactome through natural language.566Apache 2.0
io.github.rcsb/rcsb-mcpofficial
AlicenseAqualityBmaintenanceEnables discovery, inspection, and cross-referencing of Protein Data Bank structures through three RCSB APIs: search, data, and sequence coordinates.363MIT
PDBe MCP Serversofficial
AlicenseBqualityAmaintenanceProvides seamless access to the Protein Data Bank in Europe (PDBe) API and search capabilities, enabling AI clients to query protein structures, perform advanced searches, and retrieve structural biology data.3337Apache 2.0
Noctua MCP Serverofficial
AlicenseAqualityCmaintenanceEnables editing and querying of Gene Ontology Causal Activity Models (GO-CAMs) through the Barista API. Supports model creation, individual and fact management, evidence addition, and causal pathway construction for biological knowledge representation.18BSD 3-Clause- AlicenseAqualityAmaintenanceA stateless, deterministic Bio-Robotics Core Engine converting biological data (UniProt API) to G-code.6MIT

millimap-mcpofficial
AlicenseAqualityDmaintenanceEnables Claude Desktop to read and drive analyses on the active MilliMap session, including datasets, clusters, annotations, and markers.12MIT
CEDAR MCP Serverofficial
AlicenseAqualityAmaintenanceEnables interaction with the CEDAR metadata repository, including fetching templates, searching BioPortal ontology terms, and managing template instances.8MIT
WormBase MCP Serverofficial
AlicenseAqualityDmaintenanceEnables querying the WormBase database for C. elegans and nematode genomics data, including gene information, protein sequences, phenotypes, interactions, and expression patterns through natural language.1212MIT- AlicenseAqualityCmaintenanceAn MCP server that provides standardized access to biomedical knowledge bases and resources, enabling AI systems to retrieve verified information from sources like bioRxiv, EuropePMC, and various protein/gene databases.5228Apache 2.0
- AlicenseAqualityCmaintenanceProvides direct SQL access to a locally hosted Reactome database, enabling schema discovery, guarded read-only queries, and ergonomic helpers over the full relational schema.9MIT
- AlicenseAqualityDmaintenanceEnables AI agents to conversationally interact with genomics research networks for data analysis and discovery across multiple Omics AI Explorer platforms. It provides tools for exploring data collections, examining table schemas, and executing SQL queries against datasets like Viral AI and Neuroscience AI.61MIT
- AlicenseBqualityFmaintenanceEnables molecular design and simulation through 45 chemistry tools including pKa calculations, geometry optimization, conformer searches, docking, protein cofolding, and ADMET predictions powered by Rowan's computational chemistry platform.4123MIT
- AlicenseBqualityDmaintenanceProvides access to the Ensembl genomics REST API with 30+ tools for genomic data including gene lookup, sequence retrieval, genetic variants, cross-species homology, phenotypes, and regulatory features.25ISC
- AlicenseAqualityDmaintenanceEnables AI assistants to query the Ubergraph biomedical ontology SPARQL endpoint with tools for custom SPARQL queries, term lookup, search, and hierarchy traversal.4MIT
- AlicenseAqualityDmaintenanceA bioinformatics MCP server that connects AI clients to over 30 life science databases and 32 curated tools for research, drug discovery, and clinical analysis.321MIT
- AlicenseAqualityDmaintenanceEnables the generation, mutation, and evolution of DNA and protein sequences using various evolutionary models and phylogenetic algorithms. It supports realistic next-generation sequencing read simulation and population-level evolutionary tracking for bioinformatics research and testing.6BSD 2-Clause "Simplified"
- AlicenseAqualityCmaintenanceEnables genomic sequence analysis through the Evo 2 model, supporting DNA sequence scoring, embedding, generation, and variant effect prediction with multiple model checkpoints (7B, 40B, 1B parameters).62LGPL 3.0
- AlicenseAqualityDmaintenanceEnables natural language control of UCSF ChimeraX for protein structure visualization, editing, and analysis through MCP clients.393MIT
- AlicenseBqualityBmaintenancePredicts CRISPR gene dependencies and drug targets by integrating literature, regulatory/PPI networks, and genome-scale metabolic models.18Apache 2.0
- AlicenseAqualityDmaintenanceA Model Context Protocol server providing LLMs with access to the Ensembl genomics database, enabling AI assistants to query gene information, sequences, variants, and other genomic data across multiple species.108JavaScriptMIT
- AlicenseBqualityDmaintenanceMCP server providing access to the BERtron API for aggregating genomic and environmental data from multiple BER data sources, enabling geospatial search and health checks.83BSD 3-Clause
- AlicenseBqualityDmaintenanceProvides access to the STRING protein-protein interaction database for mapping identifiers, retrieving interaction networks, and performing functional enrichment analysis. It enables users to explore protein partners, pathways, and cross-species homology through natural language interactions.91ISC
- AlicenseAqualityBmaintenanceEnables gene set enrichment analysis using the Enrichr API across hundreds of gene set libraries including Gene Ontology, pathways, diseases, tissues, drugs, and transcription factors. Returns only statistically significant results for interpretation.25815MIT
- AlicenseBqualityCmaintenanceProvides comprehensive BioPython capabilities for biological sequence analysis, alignment, database access (GenBank, UniProt, PubMed), protein structure analysis, and phylogenetics through a Model Context Protocol interface for AI-assisted bioinformatics workflows.323MIT
- AlicenseBqualityDmaintenanceA Model Context Protocol server that provides tools for interacting with the STRING database to analyze protein-protein interaction networks and functional enrichment. It enables users to map protein identifiers, retrieve interaction data, and generate biological network visualizations through natural language interfaces.113BSD 3-Clause
- AlicenseAqualityCmaintenanceMCP server for single-cell lineage tracing analysis, enabling conversational reconstruction, visualization, and heritability analysis of lineage trees using Cassiopeia, pycea, and treedata.18MIT
- AlicenseAqualityAmaintenanceMCP server and Claude Plugin for a full ENCODE Project genomic data and analysis toolkit — search, download, track, and analyze functional genomics experiments208526AGPL 3.0
- AlicenseAqualityBmaintenanceA high-performance MCP server that gives LLMs access to 25 biomedical tools federated across 50+ upstream APIs for genes, variants, drugs, diseases, literature, clinical trials, and structural biology.25672MIT
- AlicenseBqualityDmaintenanceProvides seamless access to UniProtKB protein database, enabling queries for protein entries, sequences, Gene Ontology annotations, full-text search, and ID mapping across 200+ database types.52MIT
MCP ConnectorsBrowse all →
Helena Bioinformatics MCP for clinical variant interpretation, ACMG/AMP evidence and literature.
Link compounds to protein targets, rank bioactivity, and look up drug mechanisms and indications.
Search GBIF species taxonomy, occurrence records, datasets, and publishers.
Official answers about Helena Bioinformatics and its products, with citations to public sources.
InterPro MCP (EBI) — protein family / domain / functional-site classification.
EBI PRIDE Archive MCP — proteomics (mass-spectrometry) data repository.
PomBase MCP — the fission yeast (Schizosaccharomyces pombe) model-organism database.
RCSB PDB MCP — experimentally determined macromolecular structures.
Protein research over UniProtKB — search by function, fetch curated records, map IDs, proteomes.
Look up genes, sequences, variants, homologs, and cross-database xrefs from Ensembl REST.
GWAS Catalog (EBI/NHGRI) MCP — curated catalog of genome-wide association studies.
WikiPathways MCP — open community pathway database.
MetaboLights MCP — EBI's metabolomics study repository.
Look up allele frequencies by ancestry, gene constraint, variants, and coverage over gnomAD.
Query STRING interactions, enrichment, annotations, homology, and PPI networks.
Search and resolve Naturepedia, Robbie's Razor, and GC-MRD-v2.0 canonical resources.
Query CAN-IMMUNE: cancer neoantigen mutations, peptides, cell lines, MHC-I binding. Read-only.