Monarch Initiative
Server Details
Monarch Initiative MCP — biomedical knowledge graph.
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- Status
- Unhealthy
- Uptime
- 25.8% over 60 days
- Last Tested
- Transport
- Streamable HTTP
- URL
- Repository
- pipeworx-io/mcp-monarch-initiative
- GitHub Stars
- 0
- Server Listing
- mcp-monarch-initiative
TDQS
Scored across 41 tools
Several tools are nearly indistinguishable: ask_pipeworx and ask_pipeworx_beta are explicitly identical routers, and the prediction-market family (bet_research, polymarket_arbitrage, polymarket_edges, polymarket_fill_risk, polymarket_edge_tracker, polymarket_kalshi_spread) all hunt for similar mispricing opportunities with heavy description overlap. The finance trio (entity_profile, company_facts, recent_changes) also shares boundary cases. Only the Monarch KG tools (search, entity, associations, gene_to_disease, phenotype_to_gene) are cleanly distinct.
No consistent pattern: some tools use verb_noun (generate_llms_txt, resolve_entity, validate_claim), others are bare nouns (associations, entity, entity_profile), and several are noun_noun compounds (company_facts, bet_research, polymarket_arbitrage, pipeworx_trending, release_calendar_markets). Verb styles vary wildly across ask/bet/compare/discover/recall/remember/scan/search. While everything is snake_case, there is no predictable morphology to guess tool names from.
41 tools is well past the 25+ threshold for 'too many,' and the count is inflated by serving at least five unrelated domains (biomedical KG, general data lookup, prediction markets, subscription management, memory/utilities). Each subdomain is reasonably scoped on its own, but exposed as one server the surface is heavy and unfocused.
The server name promises Monarch biomedical coverage, yet only 5 of 41 tools serve that domain and obvious gap types exist (no gene_to_phenotype, no disease-to-gene reverse, no variant/orthology associations). The Pipeworx and prediction-market slices are comparatively complete within their own scopes, but the overall surface is incoherent — a user arriving for Monarch gets a mixed bag with no clear lifecycle coverage for a single domain.
Tool Schema Changelog
Recent tool additions, removals, and schema changes observed during successful MCP inspections.
29 tool updates
- Changed
ai_visibility_check1 field changed- added
Input schema / examplesAdded value: +[ + { + "entity": "Tesla" + } +]
- Changed
ask_pipeworx3 fields changed- added
Input schema / properties / askAdded value: +{ + "description": "Alias for question.", + "type": "string" +} - added
Input schema / properties / messageAdded value: +{ + "description": "Alias for question.", + "type": "string" +} - changed
Input schema / properties / question / descriptionPrevious value: -"Your question or request in natural language. Accepts query, q, prompt, text, input as aliases."New value: +"Your question or request in natural language. Accepts query, q, prompt, text, input, ask, message as aliases."
- Changed
ask_pipeworx_beta4 fields changed- added
Input schema / examplesAdded value: +[ + { + "question": "What is the current US unemployment rate?" + } +] - added
Input schema / properties / askAdded value: +{ + "description": "Alias for question.", + "type": "string" +} - added
Input schema / properties / messageAdded value: +{ + "description": "Alias for question.", + "type": "string" +} - changed
Input schema / properties / question / descriptionPrevious value: -"Your question or request in natural language. Accepts query, q, prompt, text, input as aliases."New value: +"Your question or request in natural language. Accepts query, q, prompt, text, input, ask, message as aliases."
- Changed
ask_pipeworx_grounded4 fields changed- added
Input schema / examplesAdded value: +[ + { + "question": "What was Apple's fiscal 2023 revenue?" + } +] - added
Input schema / properties / askAdded value: +{ + "description": "Alias for question.", + "type": "string" +} - added
Input schema / properties / messageAdded value: +{ + "description": "Alias for question.", + "type": "string" +} - changed
Input schema / properties / question / descriptionPrevious value: -"Your question in natural language. Accepts query, q, prompt, text, input as aliases."New value: +"Your question in natural language. Accepts query, q, prompt, text, input, ask, message as aliases."
- Added
company_facts - Changed
compare_entities1 field changed- added
Input schema / examplesAdded value: +[ + { + "type": "company", + "values": [ + "AAPL", + "MSFT" + ] + } +]
- Changed
deep_research9 fields changed- added
Input schema / examplesAdded value: +[ + { + "depth": "quick", + "question": "What is the current US unemployment rate and how has it changed over the past year?" + } +] - added
Input schema / properties / askAdded value: +{ + "description": "Alias for question.", + "type": "string" +} - added
Input schema / properties / inputAdded value: +{ + "description": "Alias for question.", + "type": "string" +} - added
Input schema / properties / messageAdded value: +{ + "description": "Alias for question.", + "type": "string" +} - added
Input schema / properties / promptAdded value: +{ + "description": "Alias for question.", + "type": "string" +} - added
Input schema / properties / qAdded value: +{ + "description": "Alias for question.", + "type": "string" +} - added
Input schema / properties / queryAdded value: +{ + "description": "Alias for question.", + "type": "string" +} - changed
Input schema / properties / question / descriptionPrevious value: -"The research question, in natural language. Broad/multi-part is fine — decomposition is the point."New value: +"The research question, in natural language. Broad/multi-part is fine — decomposition is the point. Accepts query, q, prompt, text, input, ask, message as aliases." - added
Input schema / properties / textAdded value: +{ + "description": "Alias for question.", + "type": "string" +}
- Changed
entity_profile1 field changed- added
Input schema / examplesAdded value: +[ + { + "type": "company", + "value": "AAPL" + } +]
- Changed
forget4 fields changed- added
Input schema / properties / kAdded value: +{ + "description": "Alias for key.", + "type": "string" +} - changed
Input schema / properties / key / descriptionPrevious value: -"Memory key to delete"New value: +"Memory key to delete. Accepts name, k, label as aliases." - added
Input schema / properties / labelAdded value: +{ + "description": "Alias for key.", + "type": "string" +} - added
Input schema / properties / nameAdded value: +{ + "description": "Alias for key.", + "type": "string" +}
- Changed
generate_llms_txt1 field changed- added
Input schema / examplesAdded value: +[ + { + "url": "https://pipeworx.io" + } +]
- Added
kalshi_weather_edge - Changed
pipeworx_feedback1 field changed- added
Input schema / examplesAdded value: +[ + { + "message": "Fleet #2184 smoke test: verifying pipeworx_feedback example call returns non-empty.", + "type": "other" + } +]
- Changed
pipeworx_trending1 field changed- added
Input schema / examplesAdded value: +[ + { + "window": "7d" + } +]
- Changed
polymarket_arbitrage1 field changed- added
Input schema / examplesAdded value: +[ + { + "topic": "Fed rate decision" + } +]
- Changed
polymarket_edge_tracker1 field changed- added
Input schema / examplesAdded value: +[ + { + "days": 14, + "window": "1wk" + } +]
- Changed
polymarket_edges3 fields changed- added
Input schema / examplesAdded value: +[ + { + "limit": 5, + "window": "1wk" + } +] - changed
Input schema / properties / min_edge_pp / descriptionPrevious value: -"Minimum |edge| in percentage points to include (default 0.5). Edge is evaluated NET of slippage."New value: +"Minimum |edge| in percentage points to include (default 0.5). Edge is evaluated NET of slippage and Polymarket's own taker fee." - changed
Input schema / properties / slippage_pp / descriptionPrevious value: -"Assumed execution slippage in percentage points per leg (default 0.3). Subtracted from raw |edge| before ranking and Kelly sizing. Polymarket has zero trading fees as of 2024 but bid/ask + thin depth typically eats 20-50bp per trade. Bump for very thin partitions; drop to 0 if you have a smarter fill model."New value: +"Assumed execution slippage in percentage points per leg (default 0.3), for bid/ask + thin depth cost that a last-trade price does not show. Subtracted from raw |edge| before ranking and Kelly sizing, ON TOP OF Polymarket's own taker fee — which is NOT zero (rate 0.04-0.07 depending on category, read off each market's own published fee schedule; see fees_pp_applied on every row and fees.ts for the full schedule). Bump slippage for very thin partitions; drop to 0 if you have a smarter fill model — the fee still applies regardless."
- Changed
polymarket_fill_risk1 field changed- added
Input schema / examplesAdded value: +[ + { + "market": "will-the-fed-increase-interest-rates-by-25-bps-after-the-december-2026-meeting-20260729232808636", + "side": "buy_yes", + "size_usd": 1000 + } +]
- Changed
recall4 fields changed- added
Input schema / properties / kAdded value: +{ + "description": "Alias for key.", + "type": "string" +} - changed
Input schema / properties / key / descriptionPrevious value: -"Memory key to retrieve (omit to list all keys)"New value: +"Memory key to retrieve (omit to list all keys). Accepts name, k, label as aliases." - added
Input schema / properties / labelAdded value: +{ + "description": "Alias for key.", + "type": "string" +} - added
Input schema / properties / nameAdded value: +{ + "description": "Alias for key.", + "type": "string" +}
- Changed
recent_changes1 field changed- added
Input schema / examplesAdded value: +[ + { + "since": "30d", + "type": "company", + "value": "AAPL" + } +]
- Added
release_calendar_markets - Changed
remember10 fields changed- added
Input schema / examplesAdded value: +[ + { + "key": "target_ticker", + "value": "AAPL" + } +] - added
Input schema / properties / contentAdded value: +{ + "description": "Alias for value.", + "type": "string" +} - added
Input schema / properties / dataAdded value: +{ + "description": "Alias for value.", + "type": "string" +} - added
Input schema / properties / kAdded value: +{ + "description": "Alias for key.", + "type": "string" +} - changed
Input schema / properties / key / descriptionPrevious value: -"Memory key (e.g., \"subject_property\", \"target_ticker\", \"user_preference\")"New value: +"Memory key (e.g., \"subject_property\", \"target_ticker\", \"user_preference\"). Accepts name, k, label as aliases." - added
Input schema / properties / labelAdded value: +{ + "description": "Alias for key.", + "type": "string" +} - added
Input schema / properties / nameAdded value: +{ + "description": "Alias for key.", + "type": "string" +} - added
Input schema / properties / textAdded value: +{ + "description": "Alias for value.", + "type": "string" +} - added
Input schema / properties / vAdded value: +{ + "description": "Alias for value.", + "type": "string" +} - changed
Input schema / properties / value / descriptionPrevious value: -"Value to store (any text — findings, addresses, preferences, notes)"New value: +"Value to store (any text — findings, addresses, preferences, notes). Accepts content, text, data, v as aliases; a non-string value is stored as JSON."
- Added
resolution_audit - Added
resolution_diff - Changed
resolve_entity1 field changed- added
Input schema / examplesAdded value: +[ + { + "type": "company", + "value": "AAPL" + } +]
- Changed
scan_competitor_ai_presence1 field changed- added
Input schema / examplesAdded value: +[ + { + "entities": [ + "Pipeworx", + "Zapier" + ] + } +]
- Changed
scan_dependency1 field changed- added
Input schema / examplesAdded value: +[ + { + "package": "left-pad" + } +]
- Changed
search_within1 field changed- added
Input schema / examplesAdded value: +[ + { + "query": "supply-chain risk", + "text": "Apple Inc. reported fiscal 2023 revenue of $383.285 billion, driven by strong iPhone and Services growth. Net income was $96.995 billion. The company faced supply-chain risk in China during the quarter." + } +]
- Changed
suggest_questions1 field changed- added
Input schema / examplesAdded value: +[ + { + "topic": "finance" + } +]
- Changed
validate_claim1 field changed- added
Input schema / examplesAdded value: +[ + { + "claim": "Apple's fiscal 2023 revenue was $383 billion" + } +]
2 tool updates
- Changed
bet_research2 fields changed- changed
Input schema / examplesPrevious value: -[ - { - "market": "when-will-bitcoin-hit-150k" - }, - { - "market": "https://polymarket.com/event/when-will-bitcoin-hit-150k" - } -]New value: +[ + { + "market": "will-kristi-noem-win-the-2028-republican-presidential-nomination" + }, + { + "market": "https://polymarket.com/event/will-kristi-noem-win-the-2028-republican-presidential-nomination" + } +] - changed
Input schema / properties / market / descriptionPrevious value: -"Polymarket slug (\"when-will-bitcoin-hit-150k\"), full URL (\"https://polymarket.com/event/...\"), or question text (\"Will Bitcoin hit $150k?\"). Dated slugs stop resolving once they settle — Polymarket de-indexes resolved markets — so prefer an undated one."New value: +"Polymarket slug (\"will-kristi-noem-win-the-2028-republican-presidential-nomination\"), full URL (\"https://polymarket.com/event/...\"), or question text (\"Will Bitcoin hit $150k?\"). Dated slugs stop resolving once they settle — Polymarket de-indexes resolved markets — so prefer an undated one."
- Changed
polymarket_kalshi_spread1 field changed- changed
Input schema / examplesPrevious value: -[ - { - "topic": "fed" - }, - { - "topic": "btc" - } -]New value: +[ + { + "topic": "fed" + }, + { + "topic": "btc" + }, + { + "topic": "bitcoin" + }, + { + "topic": "fed rate decision" + } +]
2 tool updates
- Changed
bet_research2 fields changed- changed
Input schema / examplesPrevious value: -[ - { - "market": "will-bitcoin-reach-100k-in-july-2026" - }, - { - "market": "https://polymarket.com/event/will-bitcoin-hit-150k-by-june-30-2026" - } -]New value: +[ + { + "market": "when-will-bitcoin-hit-150k" + }, + { + "market": "https://polymarket.com/event/when-will-bitcoin-hit-150k" + } +] - changed
Input schema / properties / market / descriptionPrevious value: -"Polymarket slug (\"will-bitcoin-hit-150k-by-june-30-2026\"), full URL (\"https://polymarket.com/event/...\"), or question text (\"Will Bitcoin hit $150k by June 30?\")"New value: +"Polymarket slug (\"when-will-bitcoin-hit-150k\"), full URL (\"https://polymarket.com/event/...\"), or question text (\"Will Bitcoin hit $150k?\"). Dated slugs stop resolving once they settle — Polymarket de-indexes resolved markets — so prefer an undated one."
- Changed
polymarket_kalshi_spread1 field changed- changed
Input schema / properties / topic / descriptionPrevious value: -"Pre-mapped: fed | btc | cpi | gdp | sp500 | recession | next_pope | next_uk_pm | next_israel_pm | 2028_president"New value: +"Subject to compare. Canonical keys: fed | btc | eth | cpi | gdp | sp500 | recession | next_pope | next_uk_pm | next_israel_pm | 2028_president — but aliases and keywords resolve too (\"bitcoin\", \"fed rate decision\", \"ethereum\", \"inflation\", \"s&p 500\", \"us recession\", \"next pope\", \"2028 election\"). Check resolution.topic_matched_by in the response: \"exact\"/\"alias\" is a curated pairing, \"phrase\"/\"token\" is a keyword guess."
Related MCP Connectors
Open Targets MCP — disease/target/drug knowledge graph.
EBI OLS4 MCP — Ontology Lookup Service.
MCP gateway federating 22 biomedical MCP servers behind one endpoint: gnomAD, ClinVar, HPO, VEP.
Bioinformatics MCP for genomic variant interpretation, gene-disease evidence and literature.
Related MCP Servers
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- AlicenseNot gradedqualityAmaintenanceRead-only biomedical MCP server connecting PubMed, ClinicalTrials.gov, ClinVar, gnomAD, OncoKB, Reactome, KEGG, UniProt, PharmGKB, CPIC, OpenFDA, Monarch Initiative, GWAS Catalog, and more. One command grammar for all biomedical entities — genes, variants, diseases, drugs, trials, articles, phenotypes, pathways, proteins, diagnostics, and adverse events. 27 tools. Apache-2.0 license.1Apache 2.0
- AlicenseNot gradedqualityAmaintenanceA unified biomedical graph database that integrates 50+ primary data sources — genes, proteins, compounds, diseases, pathways, and clinical data — into a single queryable graph with billions of cross-reference edges. Its native MCP server gives LLMs direct access to structured, authoritative biomedical data, complementing their reasoning with reliable identifiers and up-to-date database content.20AGPL 3.0

SPOKEAgentofficial
AlicenseAqualityBmaintenanceA structure-aware MCP server for querying the SPOKE biomedical knowledge graph, enabling entity resolution, schema introspection, path finding, and safe Cypher queries for biomedical knowledge inference.5Apache 2.0
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