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gene_set_enrichment

Analyze gene lists for enrichment in biological pathways and processes using GO and KEGG databases.

Instructions

Perform gene set enrichment analysis using GO and KEGG pathways via Enrichr.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
genesYesList of gene symbols (e.g., ['BRCA1', 'TP53', 'EGFR'])
databasesNoDatabases to query (default: GO_Biological_Process, KEGG)
Behavior2/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

With no annotations, the description carries full responsibility. It only states 'Perform gene set enrichment analysis' without revealing whether it is read-only, rate-limited, or produces intermediate results. No output format is specified.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness3/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is a single concise sentence, but it lacks essential details that would not be considered fluff. It is under-specified for its complexity.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness2/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

Given the absence of an output schema and annotations, the description is incomplete. It does not explain what the tool returns (e.g., enriched terms with statistics) or that it relies on an external API (Enrichr). No differentiation from siblings.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema descriptions already cover 100% of parameters, so baseline is 3. The description adds no extra meaning beyond the parameter names and default values.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose4/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly states that the tool performs gene set enrichment analysis using GO and KEGG pathways via Enrichr. It specifies a verb and resource, but lacks explicit differentiation from sibling tools like get_functional_enrichment.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines2/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

No guidance is provided on when to use this tool versus alternatives such as get_functional_enrichment or get_gene_pathways. No prerequisites or context for usage are mentioned.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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