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create_manhattan_plot

Generate a Manhattan plot from GWAS summary statistics to visualize -log10 p-values across chromosomes, highlighting significant associations.

Instructions

Create a Manhattan plot from GWAS summary statistics. Shows -log10(p-value) across chromosomes.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
sumstats_pathYesPath to GWAS summary statistics file
significance_thresholdNoGenome-wide significance threshold (default: 5e-8)
suggestive_thresholdNoSuggestive significance threshold (default: 1e-5)
output_pathNoPath to save the plot (PNG format)
titleNoPlot titleManhattan Plot
Behavior2/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

No annotations provided, so the description must fully disclose behavior. It only mentions creating a plot but lacks details on file output (overwriting, format), required summary statistics format, or any side effects.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

Two concise sentences with no extraneous words. Core purpose is front-loaded effectively.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness3/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

Adequate for a basic plot tool, but missing details like required columns in the sumstats file, plot customization aspects, and output behavior. No output schema, so description should compensate more.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

All 5 parameters have descriptions in the schema (100% coverage), so baseline is 3. The description adds minimal context (GWAS data, -log10 transformation) but does not repeat schema fields.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

Clearly states the verb 'Create', the resource 'Manhattan plot', and the context 'from GWAS summary statistics'. Distinguishes from sibling plotting tools like create_qq_plot or create_regional_plot.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines2/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

No guidance on when to use this tool versus alternatives such as Q-Q plot or regional plot. Does not specify prerequisites or use cases.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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