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clump_snps

Identifies independent significant signals from GWAS summary statistics by performing LD-based clumping, using PLINK reference and customizable thresholds for p-value, r², and window size.

Instructions

Perform LD-based clumping of GWAS results to identify independent significant signals.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
sumstats_pathYesPath to GWAS summary statistics
plink_prefixNoPath prefix for PLINK files (LD reference)
p1NoP-value threshold for index SNPs (default: 5e-8)
p2NoP-value threshold for clumped SNPs (default: 1e-4)
r2NoLD r² threshold (default: 0.5)
kbNoClumping window in kb (default: 250)
output_pathNoPath to save clumped results
Behavior2/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

With no annotations, the description carries full burden but only gives a high-level purpose. Missing behavioral traits such as whether it mutates data, performance considerations, or error conditions that would help an agent anticipate outcomes.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness4/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is a single concise sentence with no fluff. While it could be more informative, it is efficiently front-loaded and avoids redundancy.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness2/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

Given the tool has 7 parameters and no output schema, the description is insufficient. It omits the output format, required file structure, and typical usage context, leaving an agent with significant information gaps.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema coverage is 100% with clear parameter descriptions. The tool description adds no additional meaning beyond the schema, so it meets the baseline of adequate but does not enhance understanding.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose4/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly states the tool performs LD-based clumping of GWAS results to identify independent significant signals, using specific verb and resource. However, it does not differentiate from sibling tool 'ld_pruning' which performs a similar but distinct operation.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines2/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

No guidance is provided on when to use this tool versus alternatives like 'ld_pruning' or 'identify_significant_snps'. The description lacks context on prerequisites or exclusions, leaving the agent to infer usage from the name alone.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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