clump_snps
Identifies independent significant signals from GWAS summary statistics by performing LD-based clumping, using PLINK reference and customizable thresholds for p-value, r², and window size.
Instructions
Perform LD-based clumping of GWAS results to identify independent significant signals.
Input Schema
| Name | Required | Description | Default |
|---|---|---|---|
| sumstats_path | Yes | Path to GWAS summary statistics | |
| plink_prefix | No | Path prefix for PLINK files (LD reference) | |
| p1 | No | P-value threshold for index SNPs (default: 5e-8) | |
| p2 | No | P-value threshold for clumped SNPs (default: 1e-4) | |
| r2 | No | LD r² threshold (default: 0.5) | |
| kb | No | Clumping window in kb (default: 250) | |
| output_path | No | Path to save clumped results |