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Search ENCODE Experiments

encode_search_experiments
Read-onlyIdempotent

Find ENCODE experiments using comprehensive filters including assay type, organism, organ, biosample, target, and free text. Returns paginated JSON with experiment details.

Instructions

Search ENCODE experiments with comprehensive filters.

Examples:

  • Find all Histone ChIP-seq on human pancreas tissue: assay_title="Histone ChIP-seq", organ="pancreas", biosample_type="tissue"

  • Find ATAC-seq on human brain: assay_title="ATAC-seq", organ="brain"

  • Find RNA-seq on GM12878 cell line: assay_title="total RNA-seq", biosample_term_name="GM12878"

  • Find ChIP-seq targeting H3K27me3: assay_title="Histone ChIP-seq", target="H3K27me3"

  • Find all mouse liver experiments: organism="Mus musculus", organ="liver"

  • Free text search: search_term="CRISPR screen pancreatic"

Common assay_title values: "Histone ChIP-seq", "TF ChIP-seq", "ATAC-seq", "DNase-seq", "total RNA-seq", "polyA plus RNA-seq", "WGBS", "intact Hi-C", "CUT&RUN", "CUT&Tag", "STARR-seq", "MPRA", "eCLIP", "CRISPR screen"

Common organ values: "pancreas", "liver", "brain", "heart", "kidney", "lung", "intestine", "skin of body", "blood", "spleen", "thymus"

biosample_type values: "tissue", "cell line", "primary cell", "in vitro differentiated cells", "organoid"

WHEN TO USE: Use as the primary entry point when users want to find experiments. Start with encode_get_facets if unsure what filters to use. RELATED TOOLS: encode_get_facets, encode_get_metadata, encode_search_files

Args: assay_title: Assay type (e.g., "Histone ChIP-seq", "ATAC-seq", "total RNA-seq") organism: Species (default: "Homo sapiens"). Also: "Mus musculus" organ: Organ/tissue system (e.g., "pancreas", "brain", "liver") biosample_type: Sample classification ("tissue", "cell line", "primary cell", "organoid") biosample_term_name: Specific cell/tissue name (e.g., "GM12878", "HepG2", "pancreas") target: ChIP/CUT&RUN target (e.g., "H3K27me3", "CTCF", "p300") status: Data status (default: "released"). Also: "archived", "revoked" lab: Submitting lab name award: Funding project assembly: Genome assembly (e.g., "GRCh38", "mm10") replication_type: "isogenic", "anisogenic", or "unreplicated" life_stage: "embryonic", "postnatal", "child", "adult" sex: "male", "female", "mixed" treatment: Treatment name if perturbation experiment genetic_modification: Modification type ("CRISPR", "RNAi") perturbed: True for perturbation experiments only search_term: Free text search across all fields date_released_from: Start date (YYYY-MM-DD) for date range filter date_released_to: End date (YYYY-MM-DD) for date range filter limit: Max results to return (default 25, use larger for comprehensive searches) offset: Skip first N results (for pagination)

Returns: JSON with experiment results, total count, and pagination info.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
assay_titleNo
organismNoHomo sapiens
organNo
biosample_typeNo
biosample_term_nameNo
targetNo
statusNoreleased
labNo
awardNo
assemblyNo
replication_typeNo
life_stageNo
sexNo
treatmentNo
genetic_modificationNo
perturbedNo
search_termNo
date_released_fromNo
date_released_toNo
limitNo
offsetNo

Output Schema

TableJSON Schema
NameRequiredDescriptionDefault
resultYes
Behavior4/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations already declare readOnlyHint=true, destructiveHint=false, idempotentHint=true, openWorldHint=true. The description adds useful behavioral context, such as pagination via limit/offset, default status 'released', and that it returns JSON with results, total count, and pagination info. No contradictions, and the description enhances transparency beyond annotations.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness4/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is well-structured with a clear opening, examples, common values, usage guidance, and parameter list. It is front-loaded with purpose. However, it is somewhat lengthy due to the many examples and parameter details, but this is justified by the need to compensate for zero schema coverage. Nearly all sentences earn their place.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness5/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

Given the tool's complexity (21 parameters, no required fields, no enums, has output schema), the description is remarkably complete. It explains the return format (JSON with results, count, pagination), provides usage examples, lists common values, and gives guidance on when to use alternative tools. The output schema existence reduces the need to detail return values, but the description handles it well.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters5/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema description coverage is 0%, but the description provides detailed explanations for all 21 parameters, including common values, defaults, and usage examples. Examples like 'assay_title="Histone ChIP-seq", organ="pancreas", biosample_type="tissue"' illustrate how to combine parameters effectively. This fully compensates for the lack of schema descriptions.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly states 'Search ENCODE experiments with comprehensive filters.' The verb 'search' and resource 'ENCODE experiments' are specific. Examples and common values further clarify the scope, and the tool is distinguished from siblings like encode_search_files and encode_get_facets.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines5/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

The description includes explicit 'WHEN TO USE' guidance: 'Use as the primary entry point when users want to find experiments. Start with encode_get_facets if unsure what filters to use.' It also lists related tools, providing clear context for when to use this tool versus alternatives.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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