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Augmented-Nature

Unofficial PubChem MCP Server

substructure_search

Search for chemical compounds in PubChem containing a specific substructure by entering a SMILES string. Customize results with optional record limits for precise molecular analysis.

Instructions

Find compounds containing a specific substructure

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
max_recordsNoMaximum number of results (1-10000, default: 100)
smilesYesSMILES string of the substructure query

Implementation Reference

  • The handler function that executes the substructure_search tool logic. Currently implemented as a placeholder returning a 'not yet implemented' message.
    private async handleSubstructureSearch(args: any) { return { content: [{ type: 'text', text: JSON.stringify({ message: 'Substructure search not yet implemented', args }, null, 2) }] }; }
  • Input schema definition for the substructure_search tool, listed in the tools array returned by ListToolsRequestSchema handler.
    name: 'substructure_search', description: 'Find compounds containing a specific substructure', inputSchema: { type: 'object', properties: { smiles: { type: 'string', description: 'SMILES string of the substructure query' }, max_records: { type: 'number', description: 'Maximum number of results (1-10000, default: 100)', minimum: 1, maximum: 10000 }, }, required: ['smiles'], }, },
  • src/index.ts:756-757 (registration)
    Registration and dispatch case in the CallToolRequestSchema handler's switch statement that routes calls to the substructure_search handler.
    case 'substructure_search': return await this.handleSubstructureSearch(args);

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