BioMCP

Searches for biomarkers used in clinical trial eligibility criteria. This is essential for precision medicine trials that select patients based on specific biomarker characteristics. Biomarker examples: - Gene mutations (e.g., BRAF V600E, EGFR T790M) - Protein expression (e.g., PD-L1 ≥ 50%, HER2 positive) - Gene fusions (e.g., ALK fusion, ROS1 fusion) - Other molecular markers (e.g., MSI-H, TMB-high) Requires NCI API key from: https://clinicaltrialsapi.cancer.gov/ Note: Biomarker data availability may be limited in CTRP. Results focus on biomarkers used in trial eligibility criteria. Example usage: - Search for PD-L1 expression biomarkers - Find trials requiring EGFR mutations - Look up biomarkers tested by NGS - Search for HER2 expression markers

{ "properties": { "api_key": { "anyOf": [ { "type": "string" }, { "type": "null" } ], "default": null, "description": "NCI API key. Check if user mentioned 'my NCI API key is...' in their message. If not provided here and no env var is set, user will be prompted to provide one.", "title": "Api Key" }, "biomarker_type": { "anyOf": [ { "type": "string" }, { "type": "null" } ], "default": null, "description": "Type of biomarker ('reference_gene' or 'branch')", "title": "Biomarker Type" }, "name": { "anyOf": [ { "type": "string" }, { "type": "null" } ], "default": null, "description": "Biomarker name to search for (e.g., 'PD-L1', 'EGFR mutation')", "title": "Name" }, "page": { "default": 1, "description": "Page number (1-based)", "minimum": 1, "title": "Page", "type": "integer" }, "page_size": { "default": 20, "description": "Results per page", "maximum": 100, "minimum": 1, "title": "Page Size", "type": "integer" } }, "title": "nci_biomarker_searcherArguments", "type": "object" }