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Query Variant Research Database

query_variant_database
Read-onlyIdempotent

Search a local knowledge graph of genetic variants and filter by gene, clinical tier, AlphaMissense score, ClinVar class, or allele frequency to retrieve matching variants.

Instructions

Search the local knowledge graph for stored variants.

Returns variants matching the filter criteria. No upstream API calls are made — all data is served from the local SQLite knowledge graph, which is populated by the curated boot seed and by any explicit writes through the knowledge-graph storage API (the analysis tools do not write to it on their own).

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
paramsYes

Output Schema

TableJSON Schema
NameRequiredDescriptionDefault

No arguments

Behavior4/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations already declare readOnlyHint=true and idempotentHint=true. The description adds context about the data source (local SQLite knowledge graph) and that analysis tools do not write to it, which is helpful beyond annotations.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is concise with three sentences, front-loaded with the core purpose, and every sentence provides useful information without repetition.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness5/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

Given the read-only nature, detailed schema, and existence of an output schema, the description sufficiently explains what the tool does and its data source. No gaps remain for a query tool.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

The input schema already provides detailed descriptions for each parameter (e.g., gene, tier, limit). The tool description does not add any parameter information, so it adds no value beyond the schema.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly states the tool searches for stored variants in a local knowledge graph, using a specific verb and resource. It distinguishes itself from sibling tools like lookup_disease or search_diseases by focusing on variants and local data.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines4/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

The description explains that no upstream API calls are made and data is served from a local SQLite graph, implying it's for quick local queries. However, it does not explicitly state when to use this tool versus alternatives or when not to use it.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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