Find Drug Repurposing Candidates
find_drug_repurposing_candidatesDiscover drug repurposing opportunities by ranking approved and trial-stage drugs based on disease-target genetic evidence and clinical phase.
Instructions
Rank existing clinical-stage drugs as repurposing candidates for a disease.
Surfaces approved or trial-stage drugs whose target carries genetic/association
evidence for the disease — i.e. drug-repurposing hypotheses. For the full
approved-plus-pipeline drug picture of a disease (not only repurposing
candidates), use map_disease_drug_landscape instead.
How it works: take the top target_limit Open Targets evidence-scored targets
for the disease; for each, fetch its ChEMBL drugs at or above min_phase; drop
duplicate molecules; rank by
composite_repurposing_score = OT evidence score × (max ChEMBL phase / 4).
Ranking uses clinical and association evidence only — no protein structure.
Returns a JSON record whose candidates list holds up to 20 drugs (each with
ChEMBL ID, name, max phase, target gene/UniProt, OT evidence score, composite
score, and mechanism), plus the candidate count and the methodology string.
Returns an empty candidates list with a message when the disease has no
Open Targets associations. The composite score is a prioritisation aid, not an
efficacy prediction — validate mechanistically before acting on it.
Input Schema
| Name | Required | Description | Default |
|---|---|---|---|
| params | Yes |
Output Schema
| Name | Required | Description | Default |
|---|---|---|---|
No arguments | |||