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Alternatives to AlphaFold Sovereign MCP

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      A high-performance MCP server that gives LLMs access to 25 biomedical tools federated across 50+ upstream APIs for genes, variants, drugs, diseases, literature, clinical trials, and structural biology.
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    TDQS

    A3.8/5.0

    Scored across 29 tools

    Disambiguation4/5

    Descriptions do explicit work to separate near-neighbours (get_disease_targets vs get_common_disease_targets, find_drug_repurposing_candidates vs map_disease_drug_landscape, get_protein_structure vs the four structure-interpretation tools) and local-recall tools are clearly labelled as non-live. The main residual ambiguity is the variant cluster — triage_variant_3d, generate_variant_clinical_report, and classify_variant_acmg all emit variant reports, with triage_variant_3d admitting placeholders and pointing elsewhere for AlphaMissense. A careful agent can pick correctly, but these three can be confused at a glance.

    Naming Consistency5/5

    Every tool is snake_case with an action verb first (get_, query_, lookup_, search_, analyze_, score_, compute_, compare_, find_, generate_, classify_, synthesize_, export_, resolve_, map_, detect_, triage_), and resource nouns are reused consistently across the set. No camelCase or mixed convention appears.

    Tool Count3/5

    At 29 tools this is the heavy end, though the scope genuinely spans structural analysis, MONDO/HPO ontology, Open Targets/ChEMBL drug work, variant interpretation, and a local knowledge graph. Several local-store utilities (get_knowledge_graph_stats, query_variant_database, query_protein_database, export_research_dataset) are ancillary and inflate the surface for what is largely a read-only research server.

    Completeness3/5

    The read/analysis surface is broad and well covered, from structure retrieval through druggability, repurposing, and disease-phenotype traversal. However, the local knowledge graph is queried and exported but never written to — the storage API the descriptions reference is not exposed, leaving a notable dead end — and there is no sequence-level comparison or ligand-level tooling.

    Maintenance

    ActivityActive
    ResponsivenessUnresponsive