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reactome-mcp

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by reactome

reactome_compare_species

Compare human biological pathways with another species to identify orthologous pathways in Reactome.

Instructions

Compare Homo sapiens pathways to another species to identify orthologous pathways.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
pageNoPage number
speciesYesSpecies to compare (taxonomy ID or name, e.g., 'Mus musculus' or '10090')
page_sizeNoResults per page
Behavior2/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

No annotations are provided, so the description must carry the transparency burden. It only states the high-level outcome and does not disclose return format, pagination behavior, read-only nature, or any error/edge-case behavior.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is a single, front-loaded sentence that communicates the core function with no filler. Every word earns its place.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness2/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

With no output schema and no annotations, the description should explain what the tool returns and how pagination or species comparison works. It gives only the basic purpose and omits expected output structure and behavioral details.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema covers 100% of parameters with clear descriptions for species, page, and page_size. The description adds context that the comparison is always against Homo sapiens pathways, but does not provide extra parameter-level detail beyond the schema.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description names a specific operation: compare Homo sapiens pathways against another species to identify orthologous pathways. It clearly states the subject, action, and intended outcome, and this distinguishes it from sibling tools.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines2/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

No guidance is provided on when to use this tool versus alternatives like reactome_orthology, or what prerequisites exist (e.g., required species format or comparison direction). The usage context must be inferred from the name alone.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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