reactome-mcp
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- AlicenseNot gradedqualityCmaintenanceEnables AI agents to query the Reactome biological pathway knowledge-base for pathways, participants, and orthologous events using natural language.5 npmMIT
- AlicenseAqualityDmaintenanceEnables coding agents to interact with the Reactome pathway database, including search, lookup, hierarchy traversal, SBML/SBGN export, and gene-set enrichment analysis.17MIT
- AlicenseNot gradedqualityCmaintenanceEnables AI agents to query the WikiPathways open community pathway database via natural language, part of the Pipeworx MCP gateway.2 npmMIT
- FlicenseNot gradedqualityDmaintenanceEnables natural language querying and analysis of KEGG biological databases, including pathways, genes, compounds, reactions, diseases, and drugs.11-
- AlicenseAqualityCmaintenanceProvides read-only access to the ProPaths verified protein interactome, letting AI agents search proteins, retrieve mechanistic interaction details, and explore pathway ontology through MCP tools, resources, and prompts.11MIT
- AlicenseCqualityFmaintenanceProvides AI-powered access to major biological databases for GWAS and bioinformatics research. Enables natural language queries for protein, gene, variant, pathway, and drug discovery analysis.441MIT
TDQS
Scored across 56 tools
Multiple tools have unclear boundaries: reactome_get_pathway, reactome_query, and reactome_get_entity all return object details; reactome_pathways_for_entity, reactome_search_pathways_of, and reactome_mapping_pathways overlap heavily; reactome_participants and reactome_participating_physical_entities cover similar ground. Descriptions help somewhat but an agent would struggle to select the right tool.
Almost all tools use a consistent reactome_verb_noun snake_case pattern (analyze, get, export, search), and the prefix is uniform. A few noun-phrase names like reactome_entity_component_of and reactome_analysis_found_entities break the pattern, but the convention is largely predictable.
With 56 tools, the surface is extremely large. Many tools are variants (seven search tools, six export tools) that could be consolidated or parameterized, making the server overwhelming and hard to navigate. This far exceeds typical well-scoped MCP servers.
The tools cover the full read-only Reactome domain: pathway analysis, entity lookup, hierarchy navigation, exports, interactions, Cypher queries, and metadata. There are no obvious dead ends for common biological query tasks, and all major access patterns are represented.