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aria-mcp-server

aria-mcp-server

by pkotecha-eng
OverviewSchemaSourceRelated ServersDiscussionsAdmin
Python
Remote

🧬 ARIA Clinical Research MCP Server

A standalone MCP server that gives any Claude agent real-time access to biomedical literature and clinical trials — no API keys required. aria-mcp-server MCP server

Tools

Tool

Description

search_pubmed

Search 35M+ peer-reviewed papers via NCBI E-utilities

search_clinical_trials

Search 400K+ trials via ClinicalTrials.gov v2 API

search_isrctn

Search UK/European trials via ISRCTN registry

Related MCP server: ClinicalTrials.gov MCP Server — OncoHub

Prompts

Prompt

Description

clinical-research-brief

Comprehensive evidence + trial brief for a condition

adverse-event-analysis

Structured AE and safety profile for a drug

trial-eligibility-checker

Patient eligibility assessment across recruiting trials

Resources

Resource

Description

info://aria

Overview of ARIA capabilities and data sources

reference://trial-phases

Phase I–IV definitions and FDA special designations

reference://high-impact-journals

Curated high-impact journals by specialty

reference://fda-databases

FDA databases for drug, safety, and regulatory research

Example queries

Once connected, ask Claude:

  • "Search PubMed for ketogenic diet pediatric epilepsy outcomes"

  • "Find recruiting trials for lung cancer immunotherapy"

  • "What does the literature say about veliparib in ovarian cancer, and are there active trials?"

  • "Find UK and European trials for pediatric epilepsy via ISRCTN"

Quickstart

pip install aria-mcp-server
aria-mcp-server

Connect to Claude Desktop

Add to ~/Library/Application Support/Claude/claude_desktop_config.json:

{
  "mcpServers": {
    "aria-clinical-research": {
      "command": "aria-mcp-server"
    }
  }
}

Restart Claude Desktop. The server will appear under Settings → Developer → Local MCP Servers.

Data sources

  • PubMed — NCBI E-utilities (public API, no key required)

  • ClinicalTrials.gov — v2 REST API (public API, no key required)

  • ISRCTN — UK/European clinical trials registry (public API, no key required)

Tech stack

  • FastMCP — MCP server framework

  • Python 3.12+

Use cases

  • Life sciences researchers needing real-time literature access

  • Clinical trial coordinators checking eligibility and recruiting status

  • Drug discovery teams cross-referencing published evidence with active trials

  • Any Claude agent needing grounded biomedical knowledge

Project Structure

aria-mcp-server/          ← root, where mcp-publisher runs
├── aria_mcp_server/      ← Python package
│   ├── __init__.py
│   ├── server.py
│   └── tools.py
├── server.json           ← MCP registry metadata
├── pyproject.toml
├── README.md
├── LICENSE
└── glama.json

Built by

Pooja Kotecha · dinq.me/pkotecha-eng

Available Tools

3 tools
search_clinical_trialsA

Search ClinicalTrials.gov for clinical studies. Read-only operation. No authentication required. Uses ClinicalTrials.gov v2 public API (no rate limit documented). Returns up to 10 results per call. No pagination. Returns 'No clinical trials found.' if no results match. Use for: active trials, recruiting studies, inclusion/exclusion criteria, phase information, sponsor details, and trial locations.

Inputs: condition (required), status, max_results, intervention. Returns: result

search_isrctnA

Search the ISRCTN registry for UK and European clinical trials. Read-only operation. No authentication required. Complements ClinicalTrials.gov by covering trials at UK academic institutions and European research centers not listed on ClinicalTrials.gov. Returns up to 10 results per call, filtered for relevance. Returns 'No ISRCTN trials found.' if no results match. Use for: UK/European trials, academic institution studies, international coverage beyond ClinicalTrials.gov.

Inputs: query (required), max_results. Returns: result

search_pubmedA

Search PubMed for peer-reviewed biomedical literature. Read-only operation. No authentication required. Uses NCBI E-utilities public API (rate limit: ~3 requests/sec). Returns up to 10 results per call. No pagination. Returns 'No papers found.' if no results match. Use for: research papers, drug mechanisms, clinical outcomes, disease studies, safety/efficacy data, biomarkers, diagnostics, and any scientific question.

Inputs: query (required), max_results. Returns: result

Tool Schema Changelog

Recent tool additions, removals, and schema changes observed during successful MCP inspections.

Loading tool schema changelog…

    Deploy Server
    One endpoint for every MCP toolRayrun runs every MCP server behind one URL and holds the credentials. Each call is decided per client, tool, and argument, then recorded.ray.runAd

    TDQS

    A4.4/5.0

    Scored across 3 tools

    Disambiguation5/5

    Each tool targets a distinct data source: PubMed (literature), ClinicalTrials.gov (global trials), and ISRCTN (UK/European trials). The descriptions include specific use cases and overlap is minimal, so an agent can easily select the appropriate tool.

    Naming Consistency5/5

    All tools follow a clear 'search_<source>' pattern, making the naming perfectly consistent and predictable. The verb 'search' is used uniformly with the database name as the object.

    Tool Count5/5

    Three tools are appropriate for a search-focused server covering the key biomedical research databases. Each tool provides a distinct and essential capability without unnecessary bloat.

    Completeness4/5

    The server covers the main sources for biomedical literature and clinical trials, but lacks other registries (e.g., EU-CTR, WHO ICTRP). Minor gaps exist, but the core search workflows are well covered and agents can work around them.

    Maintenance

    ActivityInactive
    ResponsivenessLimited data

    Resources

    Related MCP Connectors

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