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Search cBio Mutations

search_cbio_mutations
Read-onlyIdempotent

Retrieve mutation frequencies for a gene across TCGA cancer cohorts from cBioPortal, optionally filtering by cancer type and limiting study count.

Instructions

cBioPortal cancer mutation frequencies across TCGA cohorts.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
gene_symbolYesHGNC gene symbol.
cancer_typeNoTCGA cancer type (e.g. 'luad'). Empty=pan-cancer.
max_studiesNoStudies to query Default 10.
Behavior3/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations already declare readOnlyHint=true and destructiveHint=false, so the description adds minimal safety context. It does clarify the data source (cBioPortal) and scope (TCGA), which provides some behavioral context beyond annotations.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

A single, front-loaded sentence that concisely conveys the tool's purpose with no unnecessary words. Excellent structure for quick comprehension.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness2/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

Given three parameters and no output schema, the description is too brief. It lacks information about the return format, pagination, rate limits, or how results are structured, leaving significant gaps for the agent.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema description coverage is 100%, so the schema already fully documents parameters. The description adds no additional meaning beyond what's in the schema, meeting the baseline of 3.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

Description clearly states the tool queries cBioPortal for cancer mutation frequencies across TCGA cohorts. This is specific and distinguishes it from sibling tools like bulk_gene_analysis or variant_analysis.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines2/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

No explicit guidance on when to use this tool vs alternatives or when not to use it. While the context implies use for mutation frequencies, it lacks any caveats or comparative advice.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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