aria-mcp-server
The ARIA Clinical Research MCP Server provides real-time access to biomedical literature and clinical trial data from public APIs — no API keys required.
Core Tools:
Search PubMed (
search_pubmed): Query 35M+ peer-reviewed papers via NCBI E-utilities for research on drug mechanisms, clinical outcomes, disease studies, safety/efficacy data, biomarkers, and diagnosticsSearch Clinical Trials (
search_clinical_trials): Query 400K+ studies on ClinicalTrials.gov by condition, intervention, and status (recruiting, completed, or all)
Guided Workflows (Prompts):
Generate a comprehensive evidence + trial brief for a medical condition
Produce a structured adverse event and safety profile for a drug
Assess patient eligibility across currently recruiting trials
Reference Resources:
Overview of ARIA's capabilities and data sources
Phase I–IV trial definitions and FDA special designations
Curated high-impact journals organized by medical specialty
FDA databases for drug, safety, and regulatory research
Example Use Cases:
Search literature on specific drugs, conditions, or treatment outcomes
Find actively recruiting clinical trials for a given disease
Cross-reference published evidence with active trials for drug discovery
Assess patient eligibility for clinical trials
Enables searching of 35M+ peer-reviewed papers via NCBI E-utilities, allowing comprehensive biomedical literature research through the PubMed database.
🧬 ARIA Clinical Research MCP Server
A standalone MCP server that gives any Claude agent real-time access to biomedical literature and clinical trials — no API keys required.
Tools
Tool | Description |
| Search 35M+ peer-reviewed papers via NCBI E-utilities |
| Search 400K+ trials via ClinicalTrials.gov v2 API |
| Search UK/European trials via ISRCTN registry |
Related MCP server: mcp-pubmed
Prompts
Prompt | Description |
| Comprehensive evidence + trial brief for a condition |
| Structured AE and safety profile for a drug |
| Patient eligibility assessment across recruiting trials |
Resources
Resource | Description |
| Overview of ARIA capabilities and data sources |
| Phase I–IV definitions and FDA special designations |
| Curated high-impact journals by specialty |
| FDA databases for drug, safety, and regulatory research |
Example queries
Once connected, ask Claude:
"Search PubMed for ketogenic diet pediatric epilepsy outcomes"
"Find recruiting trials for lung cancer immunotherapy"
"What does the literature say about veliparib in ovarian cancer, and are there active trials?"
"Find UK and European trials for pediatric epilepsy via ISRCTN"
Quickstart
pip install aria-mcp-server
aria-mcp-serverConnect to Claude Desktop
Add to ~/Library/Application Support/Claude/claude_desktop_config.json:
{
"mcpServers": {
"aria-clinical-research": {
"command": "aria-mcp-server"
}
}
}Restart Claude Desktop. The server will appear under Settings → Developer → Local MCP Servers.
Data sources
PubMed — NCBI E-utilities (public API, no key required)
ClinicalTrials.gov — v2 REST API (public API, no key required)
ISRCTN — UK/European clinical trials registry (public API, no key required)
Tech stack
FastMCP — MCP server framework
Python 3.12+
Use cases
Life sciences researchers needing real-time literature access
Clinical trial coordinators checking eligibility and recruiting status
Drug discovery teams cross-referencing published evidence with active trials
Any Claude agent needing grounded biomedical knowledge
Project Structure
aria-mcp-server/ ← root, where mcp-publisher runs
├── aria_mcp_server/ ← Python package
│ ├── __init__.py
│ ├── server.py
│ └── tools.py
├── server.json ← MCP registry metadata
├── pyproject.toml
├── README.md
├── LICENSE
└── glama.jsonBuilt by
Pooja Kotecha · dinq.me/pkotecha-eng
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