Click on "Install Server".
Wait a few minutes for the server to deploy. Once ready, it will show a "Started" state.
In the chat, type @ followed by the MCP server name and your instructions, e.g., "@EVEE MCP Server search for BRCA1 variants and compare their pathogenicity predictions"
That's it! The server will respond to your query, and you can continue using it as needed.
Here is a step-by-step guide with screenshots.
MCP server for the EVEE (Evo Variant Effect Explorer) API — interpretable variant effect prediction from Evo 2 genomic foundation model embeddings.
EVEE provides pre-computed pathogenicity predictions, disruption profiles, and AI-generated mechanistic interpretations for 4.2 million ClinVar variants. See Pearce et al. (2026) for the full paper.
Tool | Description |
| Autocomplete-style lookup (≤6 matches) for a gene symbol, rsID, or ClinVar variation ID; useful for finding candidate variant IDs, not an exhaustive gene-wide ranking |
| Clinical summary, EVEE-derived effect outputs, database comparison scores when present, and the AI-generated mechanistic interpretation (auto-triggers on-demand generation when not yet stored) |
| Poll EVEE's on-demand interpretation generation until it completes or times out |
| Side-by-side summary (up to 10 variants in one call) — clinical label, pathogenicity, top-1 disruption, HGVS, deep link |
| Top biological annotation disruptions ranked by magnitude, optionally scoped to a category — explains why a variant is predicted pathogenic or benign |
| Full annotation probe values (325 annotations across 13 categories), optionally filtered by category |
amino_acid, atacseq, ccre, chipseq, chromhmm, elm, fstack, protein_feature, interpro, genomic_feature, ptm, region, secondary_structure
Related MCP server: Evo2 MCP Server
A Claude Code skill lives at .claude/skills/evee/SKILL.md. Agents that load it get ~120 lines of guidance on how to use the tools effectively — workflow steps, reliability caveats by variant class, and gotchas (0-based coords, indel VCF anchoring, case-sensitivity).
Requires Python 3.10+ and uv.
git clone git@github.com:goodfire-ai/evee-mcp.git
cd evee-mcp
uv syncThe repo ships a .mcp.json; opening the directory triggers the permission prompt:
claudeAdd to claude_desktop_config.json:
{
"mcpServers": {
"evee": {
"command": "uv",
"args": ["run", "--directory", "/absolute/path/to/evee-mcp", "python3", "server.py"]
}
}
}Is the FBN1 variant rs1597537935 pathogenic, and why?
The agent searches, fetches the clinical summary with the AI-generated mechanistic interpretation, and pulls out the top disruption evidence.
Unclaimed servers have limited discoverability.
If you are the server author, to access and configure the admin panel.
Analyze biomarker panels with an MD-led clinical engine. Guideline-cited. Synthetic data only.
Broad Institute gnomAD genomic variant database (GraphQL)
MyVariant.info MCP.
We provide all the information about MCP servers via our MCP API.
curl -X GET 'https://glama.ai/api/mcp/v1/servers/goodfire-ai/evee-mcp'
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