mosaic-mcp

Pre-clinical drug discovery intelligence as an MCP server. Query 800+ drug targets, 12K+ compounds, 46K+ papers, 18K+ clinical trials, and 16K+ patents through 44 specialized tools — 16 free for discovery, 28 Pro for competitive landscapes, whitespace, and thesis-grade analysis.

Quick Start

pip install mosaic-mcp

With Claude Desktop

Add to your claude_desktop_config.json:

{
  "mcpServers": {
    "mosaic": {
      "command": "mosaic-mcp",
      "env": {
        "DATABASE_URL": "postgresql://reader:password@ep-xxx-pooler.neon.tech/mosaic_db?sslmode=require"
      }
    }
  }
}

With Claude Code

claude mcp add mosaic -- mosaic-mcp

Standalone

export DATABASE_URL="postgresql://..."
export MOSAIC_API_KEY="msk_..."       # Optional — for Pro tools
mosaic-mcp                             # stdio transport (default)
mosaic-mcp --transport sse --port 3001 # SSE for remote clients

Related MCP server: pubmed-search

Tools

Free Tier (16 tools) — discovery + workspace

Pro Tier (28 additional tools) — analysis + whitespace

The committed-verdict layer. Includes the whitespace and differentiation tools: mosaic_synthetic_lethal_whitespace, mosaic_modality_gaps, mosaic_resistance_bypass_map, mosaic_find_undruggable_targets, mosaic_talent_migration, mosaic_emerging_signals, and mosaic_assess_druggability.

Plus the full analysis set: competitive landscape, pathway context, compound selectivity, indication landscape, target validation, clinical pipeline, compound analogs, target comparison, similar-target search, opportunity finding, organization portfolio, target network, mechanism of action, evidence maps, relation search, polypharmacology, clinical trial results, FDA regulatory status, drug comparison, drug repurposing candidates, and KOL discovery.

Data Coverage

Configuration

License

Apache 2.0 for the MCP server tools. The hosted knowledge graph data requires a subscription for Pro-tier access.