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Negative results intelligence for drug discovery — query measured failures via MCP.
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Tool Definition Quality
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Available Tools
35 toolsget_compoundInspect
A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| chembl_id | No | ||
| inchi_key | No | ||
| pubchem_cid | No |
get_coverageInspect
Per-modality and per-source coverage stats (honest Phase-1 numbers).
| Name | Required | Description | Default |
|---|---|---|---|
No parameters | |||
get_finding_provenanceInspect
Full provenance + detail for a single finding by id.
| Name | Required | Description | Default |
|---|---|---|---|
| id | Yes | finding UUID |
get_model_cardInspect
Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).
| Name | Required | Description | Default |
|---|---|---|---|
| target | Yes | gene symbol or UniProt accession (required) |
get_target_landscapeInspect
Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).
| Name | Required | Description | Default |
|---|---|---|---|
| target | Yes | gene symbol or UniProt accession (required) |
list_modelsInspect
Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.
| Name | Required | Description | Default |
|---|---|---|---|
No parameters | |||
list_top_targetsInspect
Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).
| Name | Required | Description | Default |
|---|---|---|---|
| limit | No | ||
| family | No | target family filter (optional) |
search_adc_linker_failuresInspect
ADC failures attributed to linker chemistry.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_admet_failuresInspect
Small-molecule ADMET failures.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_admet_failures_all_modalitiesInspect
ADMET failures across ALL modalities.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_ancestry_specific_failuresInspect
Ancestry-specific CRISPR failures.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_bispecific_format_failuresInspect
Bispecific format/engineering failures.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_developability_failuresInspect
Antibody developability failures.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_drug_drug_interaction_failuresInspect
Drug-drug interaction failures.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_failed_adcsInspect
ADCs that failed at any stage.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_failed_bispecificsInspect
Bispecifics that failed at any stage.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_failed_clinical_antibodiesInspect
Discontinued/terminated clinical antibodies.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_failed_essentiality_screensInspect
Non-dependency / failed essentiality screens.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_failed_guidesInspect
Failed/ineffective CRISPR guides.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_failed_oligonucleotidesInspect
ASOs/siRNAs that failed engagement/developability.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_failed_peptide_therapeuticsInspect
Failed peptide therapeutics.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_failed_protacsInspect
PROTACs that failed degradation/ternary/permeability.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_failed_replicationsInspect
Findings that failed to replicate.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_failed_selectivityInspect
Small molecules that failed selectivity.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_failed_vaccinesInspect
Failed/terminated vaccines (by pathogen/indication).
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| indication | No | disease/indication |
search_inactive_compoundsInspect
Inactive small-molecule compound-target pairs.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_indication_historyInspect
ALL failed approaches for an indication across every modality.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| indication | Yes | indication (required) |
search_mechanism_failuresInspect
Approaches that failed for a mechanism (by target).
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_oligo_delivery_failuresInspect
Oligonucleotide delivery failures.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_pathogen_historyInspect
Vaccine + antimicrobial + antibody failures for a pathogen.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| pathogen | Yes | pathogen name (required) |
search_peptide_stability_issuesInspect
Peptide stability/half-life failures.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_protac_e3_issuesInspect
PROTAC E3-ligase recruitment / ternary failures.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_safety_failuresInspect
Clinical/preclinical safety failures across modalities.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
search_target_historyInspect
ALL failed approaches against a target across every modality.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | Yes | UniProt accession or gene symbol (required) |
search_vaccine_immunogenicity_failuresInspect
Failed vaccine immunogen designs.
| Name | Required | Description | Default |
|---|---|---|---|
| tier | No | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). | curated |
| limit | No | ||
| offset | No | ||
| target | No | UniProt accession or gene symbol | |
| outcome | No | outcome filter (inactive, failed_safety, terminated, …) | |
| compound | No | compound name, ChEMBL ID, or InChIKey |
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{
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