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berntpopp
by berntpopp

Get Disease Natural History

get_disease_natural_history
Read-onlyIdempotent

Query Orphanet for natural history of a rare disorder: get age of onset categories and inheritance patterns using a disease identifier.

Instructions

Return natural history data for an Orphanet disorder: age of onset categories and inheritance patterns. Signature: get_disease_natural_history(term, response_mode=).

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
termYesAn ORPHAcode (ORPHA:33069 or 33069), a disease label/synonym, or an external xref CURIE that resolves to a single Orphanet term.
response_modeNoVerbosity: minimal|compact|standard|full (default compact).compact
Behavior4/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations already declare the tool as read-only, idempotent, and non-destructive. The description adds value by specifying the exact data returned (age of onset and inheritance patterns), which is useful behavioral context beyond the annotations.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is two sentences: the first states the purpose and output, the second gives the signature. It is front-loaded, efficient, and contains no extraneous information.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness4/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

Without an output schema, the description provides the key output fields (age of onset and inheritance patterns). It lacks structural details but is sufficiently complete for a simple two-parameter tool with clear annotations.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema coverage is 100% with descriptions for both parameters. The description only restates parameter names in the signature without adding new meaning, so it meets the baseline but does not exceed it.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly states it returns natural history data for an Orphanet disorder, specifically age of onset and inheritance patterns. The verb 'Return' and resource 'natural history data' are precise, and the tool is easily distinguished from siblings like get_disease_genes or get_disease_phenotypes.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines3/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

The description implies usage for obtaining natural history information but does not explicitly state when to use this tool versus alternatives. It lacks guidance on when not to use it or mention of alternative tools for related queries.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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