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berntpopp
by berntpopp

Get Disease Natural History

get_disease_natural_history
Read-onlyIdempotent

Retrieve age of onset categories and inheritance patterns for a rare disease using an ORPHAcode, label, or external reference.

Instructions

Return natural history data for an Orphanet disorder: age of onset categories and inheritance patterns. Signature: get_disease_natural_history(term, response_mode=).

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
termYesAn ORPHAcode (ORPHA:166024 or 166024), a disease label/synonym, or an external xref CURIE that resolves to a single Orphanet term.
response_modeNoVerbosity: minimal|compact|standard|full (default compact).compact

Output Schema

TableJSON Schema
NameRequiredDescriptionDefault
successNo
_metaNo
error_codeNo
messageNo
retryableNo
recovery_actionNo
fieldNo
allowed_valuesNo
hintNo
candidatesNo
orpha_codeNo
nameNo
age_of_onsetNo
inheritanceNo
Behavior3/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations already declare readOnly, idempotent, and openWorld hints. Description adds that it returns age of onset and inheritance patterns, but no additional behavioral context beyond what schema and annotations provide.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

Two sentences: one for purpose, one for signature. No wasted words, front-loaded with key information.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness5/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

Given the tool's simplicity (2 params, 1 required, output schema present), the description is complete. All necessary information is conveyed.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema coverage is 100%, so parameters are well-documented. Description adds a signature line but does not significantly enhance meaning beyond schema descriptions.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

Clearly states the tool returns natural history data for Orphanet disorders, specifying age of onset and inheritance patterns, distinguishing it from sibling tools that focus on genes, phenotypes, or general disease info.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines3/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

Implied usage when natural history data is needed, but no explicit when-to-use or when-not-to-use guidance, nor comparison with alternatives like get_disease.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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