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unip_var_unip_var_unip_acc_6a476541

Read-only

Retrieve variation details for a UniProt accession, including protein sequence, variant features, disease associations, and PolyPhen/SIFT predictions.

Instructions

Retrieve variation details for a given UniProt accession. The response includes the protein sequence and length, UniProt identifiers, and a list of variant features with information on alternative sequences, associated diseases, evidences, genomic locations, consequence types, and predictions from tools such as PolyPhen and SIFT. Additional metadata includes clinical significance, source information, cross-references, and relevant URLs, enabling comprehensive analysis of protein sequence variations.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
uniprot_accessionYesUniProt accession. title: Uniprot Accession description: UniProt accession.

Schema Changelog

Changes observed during successful MCP inspections.

  1. Addedv1.1.10

TDQS

B3.2/5.0
Behavior3/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations already declare readOnlyHint=true and destructiveHint=false, so the safety profile is covered. The description adds value by enumerating what the payload contains (variant features, disease associations, PolyPhen/SIFT predictions), which matters because there is no output schema. It does not address pagination, size limits, or why idempotentHint is false.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness4/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The purpose is front-loaded in one short sentence, followed by a response-content enumeration that substitutes for the absent output schema. The closing clause 'enabling comprehensive analysis of protein sequence variations' is filler, but overall sizing is reasonable.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness4/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

With one required parameter, no output schema, and annotations covering the read-only safety profile, the description's payload enumeration supplies the missing return-value context. Only selection guidance relative to sibling tools is absent.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema description coverage is 100% for the single parameter, so the schema already documents 'uniprot_accession'. The description restates it as 'a given UniProt accession' without adding format, namespace, or example guidance. Baseline 3 applies.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose4/5

Does the description clearly state what the tool does and how it differs from similar tools?

The first sentence names a specific verb and resource: 'Retrieve variation details for a given UniProt accession.' This clearly separates it from siblings like unip_gen_annot or unip_ipu, even though no sibling is named explicitly.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines2/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

The description never states when to choose this tool over the many other unip_* siblings, nor any prerequisites or exclusions. Usage is only implied by the resource name, leaving the agent to infer selection.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.