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get_uniprot_variation_api_uniprot_variation__uniprot_accessi

Read-only

Retrieve comprehensive variation details for a UniProt accession, including disease associations, genomic locations, and functional predictions.

Instructions

Retrieve variation details for a given UniProt accession. The response includes the protein sequence and length, UniProt identifiers, and a list of variant features with information on alternative sequences, associated diseases, evidences, genomic locations, consequence types, and predictions from tools such as PolyPhen and SIFT. Additional metadata includes clinical significance, source information, cross-references, and relevant URLs, enabling comprehensive analysis of protein sequence variations.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
uniprot_accessionYesUniProt accession. title: Uniprot Accession description: UniProt accession.
Behavior3/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations already declare readOnlyHint=true, so the description does not need to restate that. The description adds useful context about output content but does not disclose behavioral traits like authentication requirements, rate limits, or side effects beyond what annotations provide. With annotations covering safety, this is adequate.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness4/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is a single paragraph that front-loads the main action and then lists the response contents. It is informative without being overly verbose. Minor wordiness could be trimmed, but it efficiently conveys the necessary details.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness4/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

With no output schema, the description reasonably details the response structure, including sequence, variants, diseases, predictions, etc. It covers core components but omits exact data types or nesting. For a complex tool, this is fairly complete.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

The only parameter, 'uniprot_accession,' is described in the schema as 'UniProt accession.' The description adds no additional meaning beyond that. Schema coverage is 100%, so baseline 3 is appropriate; no extra value from the description.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly states the verb 'Retrieve' and the resource 'variation details for a given UniProt accession.' It enumerates the response contents, making the tool's purpose unmistakable. There is no sibling tool that duplicates this function, so no confusion.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines4/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

While the description does not explicitly compare to sibling tools, it clearly implies when to use: when you need variation details for a UniProt accession. No exclusions or alternatives are mentioned, but the context is sufficiently clear for an agent to choose this tool based on input type.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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