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get_sequence_conservation_uniprot_api_uniprot_sequence_conse

Read-only

Get sequence conservation data from PDBe-KB for a UniProt accession. Provides residue-level conservation scores and per-residue amino acid probability profiles.

Instructions

Retrieve PDBe-KB sequence conservation data for a UniProt accession. The response provides residue-level conservation scores, per-residue amino acid probability profiles, sequence identifiers, the length of the UniProt sequence, and colors for visualizing main and sub-tracks.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
uniprot_accessionYesUniProt accession. title: Uniprot Accession description: UniProt accession.
Behavior3/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations already declare readOnlyHint=true, covering the safety profile. The description adds value by detailing the response fields (residue-level scores, probability profiles), but does not disclose additional behavioral traits beyond the retrieval action.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

Two sentences, no fluff, front-loaded with the main action and followed by concise response details. Every sentence earns its place.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness4/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

For a simple tool with one parameter and no output schema, the description lists key response fields, which is helpful. However, it lacks guidance on distinguishing from the sibling tool, slightly reducing completeness.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema description coverage is 100% for the single parameter 'uniprot_accession', which already documents its purpose. The description does not add any new semantic meaning beyond what the schema provides.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose4/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly states it retrieves PDBe-KB sequence conservation data for a UniProt accession and lists the response contents (residue-level scores, probability profiles, etc.). However, it does not differentiate from the sibling 'get_sequence_conservation_pdb_entity', which serves a similar purpose for PDB entities.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines3/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

The description implies usage for UniProt accession-based queries but provides no explicit guidance on when to use this tool versus alternatives like the PDB entity conservation tool. No exclusions or prerequisites are mentioned.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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