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get_sequence_conservation_uniprot_api_uniprot_sequence_conse

Read-only

Retrieve residue-level conservation scores and amino acid probability profiles for a UniProt sequence to analyze sequence conservation.

Instructions

Retrieve PDBe-KB sequence conservation data for a UniProt accession. The response provides residue-level conservation scores, per-residue amino acid probability profiles, sequence identifiers, the length of the UniProt sequence, and colors for visualizing main and sub-tracks.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
uniprot_accessionYesUniProt accession. title: Uniprot Accession description: UniProt accession.
Behavior3/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations provide readOnlyHint=true and destructiveHint=false. The description adds context about response contents (residue-level scores, probability profiles, etc.) but does not disclose potential errors, authentication needs, or data limitations. It adds some value beyond annotations.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is two concise sentences, front-loading the purpose and listing response details. Every word adds value, with no redundancy.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness4/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

For a single-parameter, read-only tool with no output schema, the description adequately explains the return content. It covers the main outputs and is sufficient for basic usage, though it lacks error or edge-case information.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema description coverage is 100%, so the parameter is documented. The description repeats 'UniProt accession' without adding format, validation, or example details. It meets the baseline but does not enhance parameter understanding.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly states the verb 'Retrieve' and the specific resource: 'PDBe-KB sequence conservation data for a UniProt accession.' It lists detailed response content, distinguishing it from the sibling 'get_sequence_conservation_pdb_entity' which targets PDB entities.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines3/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

The description provides no explicit guidance on when to use this tool versus alternatives. While the sibling tool names hint at the difference (UniProt vs. PDB entity), the description does not clarify usage context or exclusions.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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