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download_structure

Retrieve AlphaFold protein structure files in PDB, CIF, or BCIF formats by providing a UniProt accession ID to streamline structural biology research.

Instructions

Download AlphaFold structure file in specified format

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
formatNoFile format (default: pdb)
uniprotIdYesUniProt accession

Implementation Reference

  • The handler function that implements the download_structure tool. It fetches the structure prediction for a UniProt ID from the AlphaFold API, selects the appropriate format URL (pdb, cif, or bcif), downloads the file content, and returns it embedded in a text response.
    private async handleDownloadStructure(args: any) { if (!isValidUniProtArgs(args)) { throw new McpError(ErrorCode.InvalidParams, 'Invalid download structure arguments'); } try { const response = await this.apiClient.get(`/prediction/${args.uniprotId}`); const structures = response.data; if (!structures || structures.length === 0) { return { content: [ { type: 'text', text: `No structure available for ${args.uniprotId}`, }, ], }; } const structure = structures[0]; const format = args.format || 'pdb'; const url = format === 'pdb' ? structure.pdbUrl : format === 'cif' ? structure.cifUrl : format === 'bcif' ? structure.bcifUrl : structure.pdbUrl; const fileResponse = await axios.get(url); return { content: [ { type: 'text', text: `Structure file for ${args.uniprotId} (${format.toUpperCase()} format):\n\n${fileResponse.data}`, }, ], }; } catch (error) { return { content: [ { type: 'text', text: `Error downloading structure: ${error instanceof Error ? error.message : 'Unknown error'}`, }, ], isError: true, }; } }
  • The input schema definition for the download_structure tool as returned by ListToolsRequestSchema. Defines the expected parameters: uniprotId (string, required) and optional format (enum: pdb, cif, bcif).
    name: 'download_structure', description: 'Download AlphaFold structure file in specified format', inputSchema: { type: 'object', properties: { uniprotId: { type: 'string', description: 'UniProt accession' }, format: { type: 'string', enum: ['pdb', 'cif', 'bcif'], description: 'File format (default: pdb)' }, }, required: ['uniprotId'], }, },
  • src/index.ts:582-582 (registration)
    The case statement in the CallToolRequestSchema handler's switch that dispatches calls to the download_structure tool to its handler function.
    return this.handleDownloadStructure(args);
  • Type guard and validation function for UniProt arguments (uniprotId and optional format), used by the download_structure handler to validate input parameters.
    const isValidUniProtArgs = ( args: any ): args is { uniprotId: string; format?: 'pdb' | 'cif' | 'bcif' | 'json' } => { return ( typeof args === 'object' && args !== null && typeof args.uniprotId === 'string' && args.uniprotId.length > 0 && (args.format === undefined || ['pdb', 'cif', 'bcif', 'json'].includes(args.format)) );

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