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20 Best PDF MCP Servers: compared and ranked, November 2026Ranked from 2,140 matching servers on stars, growth, downloads and maintenance. Updated .

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    Enables language models to search biomedical literature, fetch sequences, and follow links across Entrez databases through eleven read-only tools wrapping the nine NCBI Entrez E-utilities. It handles URL building, pacing, redirects, response caps, and API-key redaction so queries can be answered without a browser or scraping.
    11
    MIT
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    quality
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    An MCP server that provides direct access to PubMed and PubMed Central via the NCBI E-utilities API. It enables AI models to search biomedical literature, retrieve detailed article metadata, and download open-access full texts.
    5
    MIT
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    An MCP server that provides mouse genetics data from Mouse Genome Informatics (MGI), enabling LLM agents to query markers, mutations, alleles, phenotypes, and disease models.
    13
    1
    MIT
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    Enables LLM clients and agents to produce realistic synthetic medical referral letter PDFs — a German Überweisungsbrief/Arztbrief or the same letter in another language — either from structured JSON with deterministic, seeded rendering or from a free-text description written by a configured LLM. Each call returns the finished PDF as an embedded resource plus the completed letter content and its seed as structured data.
    1
    MIT
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    Enables editing and querying of Gene Ontology Causal Activity Models (GO-CAMs) through the Barista API. Supports model creation, individual and fact management, evidence addition, and causal pathway construction for biological knowledge representation.
    18
    BSD 3-Clause
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    An MCP server that exposes a DICOMweb-compliant DICOM archive to AI assistants. It lets any MCP-capable client search studies, series and instances, inspect metadata, read Structured and Encapsulated PDF Reports, and render image frames — all through natural language.
    9
    50 npm
    4
    MIT
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    Enables read-only interaction with DHIS2 health data by searching indicators and querying compact analytics results, designed for small local models.
    2
    MIT
  • F
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    Exposes NeuroGraph's scientific API to AI models as MCP tools, enabling them to query, analyze, and visualize brain networks — regions, tracts, connectivity, literature, and cross-species homologies — drawn from a portable SSD-based neuroimaging data library. Lets models read real atlas data, load datasets, compute graph metrics, and produce visualization scene descriptors without acting as the scientific engine itself.
    12
    3
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    maintenance
    Enables training, predicting, evaluating, and explaining Logistic Regression and KNN models for breast cancer classification through MCP tools. It also supports model selection, SHAP explanations, and Parquet audit exports.
    8
    GPL 3.0
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    An MCP server for NONMEM pharmacometric modeling that provides structured access to model parsing, execution, and results analysis. It enables users to perform diagnostics, manage PsN workflows, and translate models to mrgsolve for PK simulations through natural language.
    22
    15
    MIT
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    Enables the generation, mutation, and evolution of DNA and protein sequences using various evolutionary models and phylogenetic algorithms. It supports realistic next-generation sequencing read simulation and population-level evolutionary tracking for bioinformatics research and testing.
    6
    BSD 2-Clause "Simplified"
  • F
    license
    A
    quality
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    maintenance
    Enables language models to query a clinical relational database through a small set of validated, row-capped tools, with evaluation of answerability and data leakage.
    4
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    license
    B
    quality
    B
    maintenance
    Enables auditable PubMed literature searches, abstract retrieval, open-access checks, and legal PDF downloads via NCBI E-utilities, while flagging missing fields rather than inferring them.
    10
    1
    Apache 2.0
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    Predicts CRISPR gene dependencies and drug targets by integrating literature, regulatory/PPI networks, and genome-scale metabolic models.
    18
    Apache 2.0
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    An MCP server that provides a toolbox for interacting with EPA SWMM stormwater models, enabling users to analyze model data and interpret results through LLM-driven tools. It assists stormwater modelers in understanding hydraulic systems and modeling behavior using natural language interfaces.
    18
    8
    MIT
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    Enables running GROMACS molecular dynamics simulations through natural language, with tools for topology building, solvation, simulation management, and trajectory processing via the Model Context Protocol.
    31
    3
    MIT
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    Provides comprehensive HIPAA compliance guidance for developers building healthcare applications. Offers tools to identify PHI, understand encryption requirements, navigate business associate rules, and ensure compliance with HIPAA Security and Privacy Rules.
    15
    2
    MIT
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    Enables querying US regulated-care providers (GLP-1 clinics) with tools for searching, retrieving details, and checking compliance, using natural language or function calls.
    2
    MIT
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    An MCP server for healthcare intake forms that lets AI agents import blank PDFs, create patient fill links, and retrieve completed PDFs while keeping PHI out of the model context.
    MIT