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Reverse Complement

seq_reverse_complement
Read-onlyIdempotent

Compute the reverse complement of DNA or RNA sequences, handling IUPAC ambiguous nucleotides for accurate downstream analysis.

Instructions

Compute the reverse complement of a nucleotide sequence (DNA or RNA).

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
sequenceYesNucleotide sequence (DNA or RNA; case-insensitive). IUPAC ambiguity codes (R, Y, S, W, K, M, B, D, H, V, N) are accepted where documented.

Output Schema

TableJSON Schema
NameRequiredDescriptionDefault
sequenceYesThe input nucleotide sequence (uppercased).
reverse_complementYesThe reverse complement of the input sequence.
Behavior3/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations already declare readOnlyHint=true, destructiveHint=false, and idempotentHint=true, covering the safety profile. The description adds that input can be DNA or RNA, which is a useful behavioral constraint beyond the annotations. However, it does not disclose output format or behavior with invalid input, though an output schema exists.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

One concise sentence that directly states the operation and input type. No redundant words or filler, making it easy to scan and understand.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness4/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

For a simple one-parameter tool with rich annotations and an output schema, this description is adequately complete. It doesn't detail return values, but the output schema covers that. The DNA/RNA mention adds useful context, and the tool's simplicity means this level of detail is sufficient.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

The input schema has 100% coverage with a detailed description of the 'sequence' parameter, including case-insensitivity and IUPAC ambiguity codes. The tool description adds no additional parameter meaning beyond what the schema already provides, so the baseline of 3 is appropriate.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly states the verb 'compute' and the resource 'reverse complement of a nucleotide sequence', distinguishing it from sibling tools like seq_translate or seq_gc_content. It is specific about DNA/RNA scope, making the purpose unambiguous.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines3/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

The description implies usage for any nucleotide sequence needing reverse complementation, but it does not explicitly contrast with alternatives or state when not to use it. The tool name and sibling list provide enough context for an agent to infer differentiation, but the description itself lacks direct guidance.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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