Get Tolerance Landscape
get_tolerance_landscapeRead-onlyIdempotent
Retrieve per-residue missense tolerance, variant counts, and Pfam domain annotations for a human transcript. Optionally specify an inclusive residue range to focus on a region.
Instructions
Return the (cache-first) MetaDome tolerance landscape for a built transcript: Pfam domains plus the paginated per-residue positional_annotation (sw_dn_ds tolerance, variant counts). Optional position_start/position_stop slice an inclusive residue range. If the build is still running this returns a first-class status='processing' success -- poll again after poll_after_s. Signature: get_tolerance_landscape(transcript_id=, position_start=, position_stop=, limit=, offset=, response_mode=).
Input Schema
TableJSON Schema
| Name | Required | Description | Default |
|---|---|---|---|
| transcript_id | Yes | A versioned Ensembl transcript id (the .N version suffix is required), e.g. ENST00000269305.4. Resolve a gene symbol with resolve_transcript first. | |
| position_start | No | ||
| position_stop | No | ||
| limit | No | Maximum rows to return (1..1000; default 200). | |
| offset | No | Zero-based offset into the result list (for paging). | |
| response_mode | No | Verbosity: minimal|compact|standard|full (default compact). | compact |
Output Schema
TableJSON Schema
| Name | Required | Description | Default |
|---|---|---|---|
| success | Yes | ||
| _meta | No | ||
| error_code | No | ||
| message | No | ||
| retryable | No | ||
| recovery_action | No | ||
| field | No | ||
| hint | No | ||
| candidates | No | ||
| recommended_citation | No | ||
| data_versions | No | ||
| transcript_id | No | ||
| gene_name | No | ||
| protein_ac | No | ||
| refseq_ids | No | ||
| domains | No | ||
| positional_annotation | No | ||
| pagination | No | ||
| status | No | ||
| poll_after_s | No |