Get Tolerance Landscape
get_tolerance_landscapeRetrieve per-residue missense tolerance and Pfam domain annotations for a human transcript by specifying a transcript ID and optional residue range.
Instructions
Return the (cache-first) MetaDome tolerance landscape for a built transcript: Pfam domains plus the paginated per-residue positional_annotation (sw_dn_ds tolerance and upstream annotations). Optional position_start/position_stop slice an inclusive residue range. If the build is still running this returns a first-class status='processing' success -- poll again after poll_after_s. Signature: get_tolerance_landscape(transcript_id=, position_start=, position_stop=, limit=, offset=, response_mode=).
Input Schema
| Name | Required | Description | Default |
|---|---|---|---|
| limit | No | Maximum rows to return (1..1000; default 200). | |
| offset | No | Zero-based offset into the result list (for paging). | |
| position_stop | No | 1-based protein residue position (inclusive range bound). | |
| response_mode | No | Verbosity: minimal|compact|standard|full (default compact). | compact |
| transcript_id | Yes | A versioned Ensembl transcript id (the .N version suffix is required), e.g. ENST00000269305.4. Resolve a gene symbol with resolve_transcript first. | |
| position_start | No | 1-based protein residue position (inclusive range bound). |