@pipeworx/opentargets

Open Targets MCP — disease/target/drug knowledge graph that integrates genetic, genomic, transcriptomic, and chemistry evidence. Keyless GraphQL public endpoint.

Part of Pipeworx — an MCP gateway connecting AI agents to 1394+ live data sources.

Tools

• target(ensembl_id) — target (gene) profile

• disease(efo_id) — disease profile

• drug(chembl_id) — drug profile

• search(query, entity?, size?) — platform search

• target_associations(ensembl_id, size?) — top diseases for a target

• disease_associations(efo_id, size?) — top targets for a disease

• target_known_drugs(ensembl_id, size?) — clinically tested drugs for a target

Related MCP server: mcp-chembl

Data source

https://api.platform.opentargets.org/api/v4/graphql

Quick Start

Add to your MCP client (Claude Desktop, Cursor, Windsurf, etc.):

{
  "mcpServers": {
    "opentargets": {
      "url": "https://gateway.pipeworx.io/opentargets/mcp"
    }
  }
}

Or connect to the full Pipeworx gateway for access to all 1394+ data sources:

{
  "mcpServers": {
    "pipeworx": {
      "url": "https://gateway.pipeworx.io/mcp"
    }
  }
}

Using with ask_pipeworx

Instead of calling tools directly, you can ask questions in plain English:

ask_pipeworx({ question: "your question about Opentargets data" })

The gateway picks the right tool and fills the arguments automatically.

More

• Docs and guides

• pipeworx.io

License

MIT