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guidetopharmacology

by pipeworx-io

mcp-guidetopharmacology

IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) MCP — keyless.

Part of Pipeworx — an MCP gateway connecting AI agents to 1394+ live data sources.

Tools

Tool

Description

search_ligands

Search the Guide to PHARMACOLOGY (IUPHAR/BPS) — an expert-curated pharmacology database — for drug ligands by name. Returns matching ligands with their GtoPdb ligand id, type (e.g. Synthetic organic, Peptide, Antibody, Metabolite), and approval status. Use the returned ligand id with ligand_interactions to find which protein targets it acts on. Keyless. Complements ChEMBL/DrugBank.

search_targets

Search the Guide to PHARMACOLOGY (IUPHAR/BPS) — an expert-curated pharmacology database — for protein targets by name. Returns matching targets with their GtoPdb target id, abbreviation, and type (e.g. GPCR, CatalyticReceptor, Enzyme, Transporter). Use the returned target id with target_interactions to find ligands that bind it. Keyless. Complements ChEMBL/DrugBank.

target_interactions

List the quantitative ligand interactions for a protein target in the Guide to PHARMACOLOGY (IUPHAR/BPS). Given a GtoPdb target id (from search_targets), returns the ligands acting on it with interaction type (Agonist/Antagonist/Inhibitor/etc.), action, and binding affinity (e.g. pKi/pIC50). Keyless.

ligand_interactions

List the quantitative target interactions for a drug ligand in the Guide to PHARMACOLOGY (IUPHAR/BPS). Given a GtoPdb ligand id (from search_ligands), returns the protein targets it acts on with interaction type (Agonist/Antagonist/Inhibitor/etc.), action, and binding affinity (e.g. pKi/pIC50). Keyless.

Related MCP server: Open Targets Platform MCP

Quick Start

Add to your MCP client (Claude Desktop, Cursor, Windsurf, etc.):

{
  "mcpServers": {
    "guidetopharmacology": {
      "url": "https://gateway.pipeworx.io/guidetopharmacology/mcp"
    }
  }
}

Or connect to the full Pipeworx gateway for access to all 1394+ data sources:

{
  "mcpServers": {
    "pipeworx": {
      "url": "https://gateway.pipeworx.io/mcp"
    }
  }
}

Using with ask_pipeworx

Instead of calling tools directly, you can ask questions in plain English:

ask_pipeworx({ question: "your question about Guidetopharmacology data" })

The gateway picks the right tool and fills the arguments automatically.

More

License

MIT

A
license - permissive license
-
quality - not tested
C
maintenance

Maintenance

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Releases (12mo)
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Related MCP Servers

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Related MCP Connectors

  • Link compounds to protein targets, rank bioactivity, and look up drug mechanisms and indications.

  • Open Targets MCP — disease/target/drug knowledge graph.

  • Query STRING interactions, enrichment, annotations, homology, and PPI networks.

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