genefoundry
Click on "Install Server".
Wait a few minutes for the server to deploy. Once ready, it will show a "Started" state.
In the chat, type
@followed by the MCP server name and your instructions, e.g., "@genefoundrysearch for BRCA1 variant details in gnomAD"
That's it! The server will respond to your query, and you can continue using it as needed.
Here is a step-by-step guide with screenshots.
genefoundry-router
A thin FastMCP 3.x aggregator that federates the GeneFoundry *-link MCP fleet behind a
single Streamable-HTTP endpoint. A host adds one server — genefoundry — and gets every
biomedical backend with collision-free <namespace>_<tool> naming and search-based discovery.
Research use only. Not clinical decision support. Do not use for diagnosis, treatment, triage, or patient management.
Why
An MCP host that mounted all 21 backends directly would face a wall of several hundred tools — more than a model can reason over, and a guarantee of name collisions. The router collapses that into one endpoint and replaces the flat catalog with a search surface, so a model finds the right tool by intent instead of by scrolling.
It is a client to each backend and a server to hosts: it namespaces and shapes the surface, but never rewrites a backend's data. The caller's token is never forwarded upstream.
Related MCP server: mcpproxy-go
Quick start
The fleet is hosted — no install required:
claude mcp add --transport http genefoundry https://genefoundry.org/mcpHealth check: genefoundry.org/health.
To run your own against the live fleet (Python 3.12+, uv):
uv sync --group dev
cp .env.example .env # set GF_*_URL backend URLs and GF_AUTH_MODE
uv run genefoundry-router run --host 127.0.0.1 --port 8000
curl -s localhost:8000/health | python -m json.toolAn offline fake fleet (make dev-fleet + make run-dev, or one-shot make test-e2e) runs
the real router against impersonated backends over real Streamable-HTTP — no Docker, no
network.
Tools
The router does not surface the federated catalog flat. A model sees three things:
Tool | Purpose |
| Relevance search over the entire federated catalog |
| Invoke a hit by its |
pinned entry points | Each backend's front-door tool, always visible — declared per-backend as |
search_tools(query="splicing prediction") # → spliceai_predict_splicing (+ schema)
call_tool(name="spliceai_predict_splicing", arguments={...})Pinning makes each domain's canonical tool reachable deterministically rather than by relevance luck. See How discovery works — including the two traps that bite MCP clients.
Federated backends
21 backends, 272 tools, each surfaced namespaced — e.g. gnomad_search_genes.
Namespace | Domain | Data source | Tools | Repo |
| Literature & entity annotation | 35 | ||
| Variant / gene / population frequency | 22 | ||
| Rare disease ontology & associations | 19 | ||
| Gene–disease curation | 17 | ||
| Phenotype ontology & associations | 17 | ||
| Variant-effect assay scores | 15 | ||
| Protein function | 15 | ||
| Gene–disease literature | 13 | ||
| Mouse phenotype & models | 13 | ||
| Disease ontology / cross-references | 13 | ||
| Gene–disease curation | 12 | ||
| Protein tolerance landscapes | 11 | ||
| Protein–protein interaction networks | 10 | ||
| Tissue expression | 9 | ||
| Gene nomenclature | 9 | ||
| Diagnostic gene panels & curation | 9 | ||
| Variant ACMG PVS1 | 7 | ||
| Splicing prediction | 7 | ||
| Variant annotation / consequence | 7 | ||
| Variant clinical significance | 6 | ||
| Variant literature | 6 |
Data & provenance
The router serves no data of its own; each backend owns its sources, licences and citation guidance, and the router mirrors their disclaimers.
What it does own is integrity of the tool surface. A backend can serve a clean tool at
review time and later change its definition — the channel for a rug pull. The router
fingerprints every normalized tool definition and diffs the live fleet against a reviewed,
packaged baseline (genefoundry_router/data/fleet-baseline.json), enforced at startup and
on a schedule. See Deployment → drift detection.
Documentation
Configuration & authentication — every
GF_*variable, the OAuth/JWT resource-server modes, and the startup guards.Deployment — container release, digest pinning, rollback, and drift detection.
How discovery works — the search surface, entry-point pinning, and how discoverability is measured.
Design spec — the architecture and why it is shaped this way.
Fleet standards — Tool-Naming · Response-Envelope · MCP-Behaviour · Tool-Surface-Budget · Tool-Schema-Documentation · Container-Hardening · Versioning · README.
Contributing
See AGENTS.md for engineering conventions. make ci-local is the
definition-of-done gate: format, lint, line budget, README standard, mypy, and tests.
License
MIT © Bernt Popp. Each federated backend carries the licence and citation terms of its upstream data source; see that backend's repository.
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