breedsim-mcp

Breeding-scheme simulation over MCP — returns distributions, never a single stochastic run.

Drives AlphaSimR so an agent can ask what a selection programme would actually gain, with one structural rule: a single simulation run is not a result, and this API will not return one.

Measured on AlphaSimR 2.1.0 — five seeds of an identical three-cycle programme gave mean genetic gain [1.151, 1.841, 1.424, 1.429, 1.473]: sd 0.247 on the very number being reported. Quoting one run to three decimals reports noise with the authority of a measurement. So run_program enforces a replicate floor and returns per-cycle mean, sd and confidence interval. There is no flag that collapses it to a point estimate.

Unofficial. Not affiliated with, endorsed by, or sponsored by the AlphaSimR authors, the University of Edinburgh, or the R Foundation. See NOTICE.

Status

0.1.0 is on PyPI. 5 tools, 38 tests against real AlphaSimR, and 15 mutation checks all confirmed red (docs/MUTATION-CHECKS.md). CI installs R and compiles AlphaSimR, so the suite runs against the real engine on Python 3.11, 3.12 and 3.13 — not against a mock.

Related MCP server: PBPK MCP Server

Install tax — read this first

Heavier than uv pip install, and the reasons are not negotiable:

• R ≥ 4.3 with a shared library (libR.so)

• AlphaSimR — an Rcpp/RcppArmadillo compile, minutes not seconds

• libtirpc-dev — rpy2 fails to link without it (cannot find -ltirpc)

• rpy2 pinned <3.6 — 3.6 binds R_getVar, which needs R ≥ 4.4

sudo apt-get install -y r-base r-base-dev libtirpc-dev
R -e 'install.packages("AlphaSimR", repos="https://cloud.r-project.org")'
uv add breedsim-mcp

If you build against a conda Python, rpy2 will fail to load libR.so with GLIBCXX_3.4.30 not found — conda ships an older libstdc++ than system libicuuc requires. Use a system or uv-managed interpreter.

Configure your MCP client

The server speaks stdio; the installed console script is breedsim-mcp.

Claude Code

claude mcp add breedsim -- breedsim-mcp

Claude Desktop — add to claude_desktop_config.json:

{
  "mcpServers": {
    "breedsim": {
      "command": "breedsim-mcp"
    }
  }
}

If the executable is not on your PATH, or AlphaSimR lives in a user library, invoke it through uv and pass the library path:

{
  "mcpServers": {
    "breedsim": {
      "command": "uv",
      "args": ["run", "--directory", "/path/to/breedsim-mcp", "breedsim-mcp"],
      "env": { "R_LIBS_USER": "/home/you/R/library" }
    }
  }
}

Verify with list_methods(), which reports the engine versions and whether this process can currently produce reproducible results.

Tools

Typical loop: found_population → run_program → read the CI and the warnings. Comparing two schemes: found_population → compare_programs → read difference.

Species

species applies only to runMacs, which carries demographic histories for exactly four: GENERIC, CATTLE, WHEAT, MAIZE (read out of body(runMacs), not the docs). Anything else is refused here rather than failing inside R. Casing does not matter — AlphaSimR upper-cases it, so this does too.

Note the scope that implies: two plants and an animal. Despite the default of MAIZE, this is not a plant-only simulator.

What run_program returns

Verbatim, for cycles=2, replicates=10, abridged to one cycle:

{
  "session_id": "bs-...",
  "replicates": 10,
  "cycles": [
    {
      "cycle": 2,
      "genetic_gain": {
        "mean": 1.5941703785773211,
        "sd": 0.1414620049281876,
        "ci_low": 1.4929815869737013,
        "ci_high": 1.695359170180941,
        "n": 10
      },
      "genetic_variance": {
        "mean": 0.5149269761002959,
        "sd": 0.15228915685789685,
        "ci_low": 0.4059934446929936,
        "ci_high": 0.6238605075075982,
        "n": 10
      }
    }
  ],
  "reproducible": true,
  "recipe": {
    "generator": "quickHaplo",
    "seed": 1,
    "n_select": 10,
    "n_cross": 60,
    "base_seed": 1000
  },
  "warnings": []
}

There is no value field anywhere. Intervals use t critical values rather than a normal 1.96, because at n = 5–10 the normal understates the interval — the wrong direction to be wrong in when the interval exists to be honest.

Comparing two programmes

Do not call run_program twice and compare the means. Use compare_programs, which pairs the two arms on the same seeds — replicate i of A and replicate i of B start from identical founders under an identical seed — and differences them within each pair, so the shared luck of that seed cancels instead of being counted twice.

Read difference and favours. favours is null when the interval contains zero, which means the two programmes are not distinguishable at that replicate count; the larger mean is then not the better programme.

Here is why the pairing earns its keep. Verbatim, selecting 12 of 100 against 18 of 100, final cycle of two, ten replicates:

{
  "programs": {
    "a": { "label": "A", "n_select": 12, "n_cross": 100 },
    "b": { "label": "B", "n_select": 18, "n_cross": 100 }
  },
  "cycles": [
    {
      "cycle": 2,
      "a_genetic_gain": {
        "mean": 2.046227841067686,
        "ci_low": 1.9001469542399823,
        "ci_high": 2.1923087278953903,
        "n": 10
      },
      "b_genetic_gain": {
        "mean": 1.730473406465538,
        "ci_low": 1.5520780571733739,
        "ci_high": 1.9088687557577022,
        "n": 10
      },
      "difference": {
        "mean": 0.31575443460214814,
        "ci_low": 0.10028439648886733,
        "ci_high": 0.5312244727154289,
        "n": 10
      }
    }
  ],
  "favours": "a",
  "intervals_overlap": true,
  "warnings": [{ "code": "overlap_but_different", "message": "..." }]
}

The two per-programme intervals overlap — A spans 1.900–2.192, B spans 1.552–1.909 — so reading them side by side says "no difference". The paired difference says otherwise: [+0.100, +0.531], entirely above zero. Pairing cancels the seed-to-seed variation that made both individual intervals wide, so it resolves a contrast that eyeballing the overlap cannot. That is what overlap_but_different is for.

Two overlapping confidence intervals do not imply no difference. This is the single easiest way to get a breeding comparison wrong, and it is why the tool reports a difference rather than two numbers.

Warnings

None of these withhold results. Outputs are always distributions, so you can already see when an answer is too noisy to use — they explain rather than refuse.

Reproducibility

Two independent things break it, and both were measured:

The runMacs case is subtler than "it ignores the seed". Its MaCS RNG is seeded once per R session and advances across calls, so the same call sequence reproduces in a fresh process while a repeat call inside one session does not. Since this server is a long-lived process, the repeat case is the one you hit — hence reproducible: false.

The server pins threads at import, before rpy2 loads, and reports whether it succeeded. With founders fixed and threads pinned, seed 7 reproduces exactly: meanG=2.01451853, twice.

Limitations (phase 1)

No genomic selection models (GBLUP/RR-BLUP), no multi-trait or G×E, no optimal contribution selection, no crossing-block optimisation, no genotype-matrix export. Truncation selection on phenotype only. Genomic selection is the next thing worth building; compare_programs has landed.

Sessions are in-memory and capped (8, LRU); they do not survive a restart.

Licence

GPL-3.0-or-later — because this imports rpy2, which is GPLv2+. AlphaSimR itself is MIT; the licence here is about rpy2, not about AlphaSimR. See NOTICE.

More

• CHANGELOG.md — what changed, and why

• docs/MUTATION-CHECKS.md — every guard disabled on purpose, and the test that went red for it