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get_variants_for_region

Retrieve genetic variants within a specified genomic region to analyze DNA sequence variations for research or diagnostic purposes.

Instructions

Get genetic variants for a genomic region

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
speciesNoSpecies namehuman
regionYesGenomic region (e.g., 7:140424943-140624564)
Behavior2/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

With no annotations provided, the description carries full burden for behavioral disclosure. It states what the tool does but doesn't describe how it behaves: no information about response format, pagination, rate limits, authentication requirements, or error conditions. This leaves significant gaps for an agent to understand operational characteristics.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is a single, efficient sentence that states the core purpose without unnecessary words. It's appropriately sized for a simple retrieval tool and front-loads the essential information.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness2/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

For a tool with no annotations and no output schema, the description is insufficiently complete. While concise, it doesn't address critical contextual elements like what format variants are returned in, whether there are limitations on region size, how results are structured, or what happens with invalid inputs. The agent lacks necessary operational understanding.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema description coverage is 100%, so the schema already documents both parameters thoroughly. The description doesn't add any additional meaning beyond what's in the schema - it doesn't explain parameter relationships, provide examples beyond the schema's region example, or clarify edge cases. This meets the baseline for high schema coverage.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose4/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly states the action ('Get') and resource ('genetic variants for a genomic region'), making the purpose immediately understandable. It doesn't explicitly differentiate from sibling tools like 'overlap_region' or 'vep_region' that might also operate on genomic regions, but the specificity of 'genetic variants' provides reasonable distinction.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines2/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

No guidance is provided on when to use this tool versus alternatives. Sibling tools like 'overlap_region' or 'vep_region' might serve similar purposes with different outputs, but the description offers no comparison or context about appropriate use cases.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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