Search for chemicals by name, CAS-RN, or other identifiers

Batch search for chemicals using a list of identifiers

Resolve a chemical identifier deterministically without silently accepting ambiguous fuzzy matches

Get detailed information about a chemical

Get detailed information about multiple chemicals

Search for chemicals by MS-ready properties

Retrieve environmental fate summary for a chemical

Retrieve detailed environmental fate data for a chemical

Fetch extra chemical data (functional use, use cases, etc.)

Convert a systematic name using OPSIN

Convert a molfile using Indigo toolkit endpoints

Search bioactivity terms by prefix, exact match, or substring

Fetch bioactivity summary data for a chemical

Fetch bioactivity summary data for an assay endpoint ID (AEID)

Fetch bioactivity summary data for a chemical in a specific tissue

Retrieve detailed bioactivity data for a single identifier

Batch fetch bioactivity data for multiple identifiers

Retrieve Activity Exposure Distribution (AED) data for a chemical

Batch retrieve AED data for multiple chemicals

Retrieve assay annotations or lists (by AEID, gene, single-concentration, or all)

Batch retrieve assay annotations for AEIDs

Return the total count of available assays

Get chemicals associated with an assay endpoint

Retrieve adverse outcome pathway mappings

Retrieve analytical QC data for a chemical

Search historical CPDat data (functional use, product use categories, or list presence) for chemicals

Search for high-throughput toxicokinetics (HTTK) data

Return CPDat controlled vocabulary values (functional use, product use categories, or list presence tags)

Retrieve QSUR model functional-use probability predictions

Backwards-compatible exposure search across pathways/MMDB/SEEM datasets

Fetch SEEM general exposure predictions

Batch fetch SEEM general exposure predictions

Fetch SEEM demographic exposure predictions

Batch fetch SEEM demographic exposure predictions

Retrieve CPDat product data

Batch fetch CPDat product data

List product use categories (PUC)

Retrieve list presence data

Batch fetch list presence data

List list-presence tags

Retrieve HTTK data

Batch fetch HTTK data

Retrieve reported functional use data

Batch fetch reported functional use data

Retrieve functional use probability predictions

List functional use categories

Retrieve CCD Product Use Category data

Retrieve CCD production volume data

Retrieve CCD biomonitoring data

Retrieve CCD general use keywords

Retrieve CCD reported functional use data

Retrieve CCD chemical weight fractions data

Retrieve MMDB single-sample data filtered by medium

Retrieve MMDB single-sample data

List MMDB medium categories

Retrieve MMDB aggregate records filtered by medium

Retrieve MMDB aggregate records

Search for hazard data by DTXSID across ToxValDB, ToxRefDB, cancer, genetox, ADME/IVIVE, IRIS, PPRTV, or HAWC datasets.

Batch hazard lookup for multiple DTXSIDs for the selected dataset.

Retrieve full ToxValDB hazard data for a single chemical.

Retrieve ToxValDB hazard data for multiple chemicals.

Retrieve skin and eye hazard data for a single chemical.

Retrieve skin and eye hazard data for multiple chemicals.

Retrieve cancer hazard summary for a single chemical.

Retrieve cancer hazard summary for multiple chemicals.

Retrieve genotoxicity summary data for a chemical.

Retrieve genotoxicity summary data for multiple chemicals.

Retrieve genotoxicity detailed data for a chemical.

Retrieve genotoxicity detailed data for multiple chemicals.

Retrieve ADME/IVIVE hazard data for a chemical.

Retrieve PPRTV hazard data for a chemical.

Retrieve IRIS hazard data for a chemical.

Retrieve HAWC link mapper data for a chemical.

Retrieve ToxRefDB data (summary, data, effects, or observations) by DTXSID, study ID, or study type.

Batch retrieve ToxRefDB data by DTXSID.

Get names of available public chemical lists

Get all chemicals in a specific list

Retrieve CompTox model cards with optional filters and pagination

List applicability domain reference definitions

Fetch applicability domain configuration for a specific model

Assemble a portable CompTox evidence pack combining identity, hazard, exposure, bioactivity, AOP linkage, and PBPK context slices.

Build a CompTox-side AOP linkage summary from bioactivity assay and AOP crosswalk data.

Build a CompTox-side PBPK context bundle from HTTK, ADME/IVIVE, exposure hints, and model-card references.

Build a caveated screening-priority summary from bioactivity AED, SEEM exposure, HTTK context, MMDB, and CPDat use signals

Return a machine-readable inventory of the live public resources, tools, MCP response schemas, portable schemas, and suite boundary notes