Run a forward pass of Evo2-7B on a DNA sequence (forward inference) and return summary statistics — or raw tensors — for the requested model layers (final logits, attention, MLP or embedding outputs). Use this when you need layer outputs for analysis, not just a scalar score. Modes: 'summary' (shape/dtype/min/max/mean/std per layer — default, context-safe), 'save' (write the .npz under the server's output dir and return the path), 'raw' (inline small tensors only; large tensors must be saved to a file instead). This is a DNA foundation model inference tool. It does not provide clinical diagnosis. Model scores should not be interpreted as pathogenicity labels without additional validation.

Compute the model-based log-likelihood of a DNA sequence under Evo2-7B (nucleotide-level log-likelihood via the byte-level tokenizer). Returns total_log_likelihood, mean_log_likelihood, scored_positions and optionally per_position_log_likelihood (position 0 is unscored by the causal shift; value k corresponds to 0-based position k+1). Use for sequence-level probability estimates. This is a DNA foundation model inference tool. It does not provide clinical diagnosis. Model scores should not be interpreted as pathogenicity labels without additional validation.

Compare a single-nucleotide variant: the Evo2-7B log-likelihood of the wildtype sequence vs the mutant sequence. Returns delta_log_likelihood (mutant − wildtype); a negative value means the mutant sequence is LESS likely under the model. Positions are 1-based by default (VCF-style). Variants at position 1 are rejected because a causal LM cannot score the first base. This is a DNA foundation model inference tool. It does not provide clinical diagnosis. Model scores should not be interpreted as pathogenicity labels without additional validation.

Score many single-nucleotide variants against one wildtype sequence. The WT forward pass is computed exactly once and reused; identical (position, alt) mutants are forwarded once; mutant requests run with bounded concurrency (EVO2_MCP_MAX_CONCURRENCY, default 2) to respect NVIDIA rate limits, and per-variant API errors are reported per-variant. Use for saturation-mutagenesis-style analyses. This is a DNA foundation model inference tool. It does not provide clinical diagnosis. Model scores should not be interpreted as pathogenicity labels without additional validation.

Score every record in a FASTA source under Evo2-7B. Provide EITHER fasta_text (inline FASTA) OR fasta_path (local file — only allowed when its directory is listed in EVO2_MCP_ALLOWED_DIRS; the server refuses arbitrary paths). Returns per-record total/mean log-likelihood; per-record errors are reported inline. This is a DNA foundation model inference tool. It does not provide clinical diagnosis. Model scores should not be interpreted as pathogenicity labels without additional validation.