/**
* Enhanced FDA Market Intelligence Prompt
* Implements AI Assistant Prompt Enhancement PRD specifications
* FDA-focused market intelligence analysis including patent protection timelines,
* generic competition risks, and regulatory pathway impacts on market access
*/
import { EnhancedPrompt, WorkingExample } from './enhanced-base.js';
import { PromptExecutionResult } from '../types/index.js';
import { FdaSearchType } from '../types/fda.js';
import { z } from 'zod';
interface MarketIntelArgs {
drug_name?: string;
company_name?: string;
brand_name?: string;
generic_name?: string;
nda_number?: string;
}
export class MarketIntelPrompt extends EnhancedPrompt<MarketIntelArgs> {
constructor() {
super(
'fda_market_access_analysis',
'FDA-focused market intelligence analysis including patent protection timelines, generic competition risks, and regulatory pathway impacts on market access for investment decision-making.',
{
drug_name: z.string().optional().describe('Name of the drug to analyze for market intelligence'),
company_name: z.string().optional().describe('Name of the company to analyze for market intelligence'),
brand_name: z.string().optional().describe('Brand name of the drug for market analysis'),
generic_name: z.string().optional().describe('Generic name of the drug for market analysis'),
nda_number: z.string().optional().describe('NDA/BLA application number for market analysis')
}
);
}
protected async execute(
params: MarketIntelArgs,
_requestId: string
): Promise<PromptExecutionResult> {
const { drug_name, company_name, brand_name, generic_name, nda_number } = params;
// Use placeholders if not provided
const companyName = company_name || '[COMPANY_NAME]';
const brandName = brand_name || '[BRAND_NAME]';
const genericName = generic_name || '[GENERIC_NAME]';
const ndaNumber = nda_number || '[NDA_NUMBER]';
const searchEntity = drug_name || company_name || brandName;
// Base prompt content with corrected queries
const basePrompt = `Generate FDA-focused market intelligence for ${searchEntity}:
1. Company portfolio marketing status distribution:
- Tool: fda_info
- EXECUTE EXACTLY:
{
"method": "lookup_drug",
"search_term": "sponsor_name:\\"${companyName}\\"",
"search_type": "general",
"count": "products.marketing_status",
"limit": 15
}
2. Company regulatory submission activity:
- Tool: fda_info
- EXECUTE EXACTLY:
{
"method": "lookup_drug",
"search_term": "sponsor_name:\\"${companyName}\\"",
"search_type": "general",
"count": "submissions.submission_type",
"limit": 10
}
3. Application number and therapeutic equivalence:
- Tool: fda_info
- EXECUTE EXACTLY:
{
"method": "lookup_drug",
"search_term": "application_number:\\"${ndaNumber}\\"",
"search_type": "general",
"limit": 1,
"fields_for_general": "application_number"
}
4. Therapeutic equivalence code analysis:
- Tool: fda_info
- EXECUTE EXACTLY:
{
"method": "lookup_drug",
"search_term": "application_number:\\"${ndaNumber}\\"",
"search_type": "general",
"limit": 1,
"fields_for_general": "products.te_code"
}
5. Brand and generic name mapping:
- Tool: fda_info
- EXECUTE EXACTLY:
{
"method": "lookup_drug",
"search_term": "application_number:\\"${ndaNumber}\\"",
"search_type": "general",
"limit": 1,
"fields_for_general": "openfda.brand_name"
}
6. Generic name verification:
- Tool: fda_info
- EXECUTE EXACTLY:
{
"method": "lookup_drug",
"search_term": "application_number:\\"${ndaNumber}\\"",
"search_type": "general",
"limit": 1,
"fields_for_general": "openfda.generic_name"
}
7. Generic competition landscape:
- Tool: fda_info
- EXECUTE EXACTLY:
{
"method": "lookup_drug",
"search_term": "openfda.generic_name:\\"${genericName}\\" AND products.marketing_status:Prescription",
"search_type": "general",
"count": "sponsor_name",
"limit": 10
}
8. Submission class codes for regulatory pathway:
- Tool: fda_info
- EXECUTE EXACTLY:
{
"method": "lookup_drug",
"search_term": "products.brand_name:\\"${brandName}\\"",
"search_type": "general",
"limit": 5,
"fields_for_general": "submissions.submission_class_code"
}
9. Submission status timeline:
- Tool: fda_info
- EXECUTE EXACTLY:
{
"method": "lookup_drug",
"search_term": "products.brand_name:\\"${brandName}\\"",
"search_type": "general",
"limit": 5,
"fields_for_general": "submissions.submission_status"
}
10. Current marketing status verification:
- Tool: fda_info
- EXECUTE EXACTLY:
{
"method": "lookup_drug",
"search_term": "products.brand_name:\\"${brandName}\\"",
"search_type": "general",
"limit": 1,
"fields_for_general": "products.marketing_status"
}
**Analysis Framework (FDA-adapted):**
- Portfolio strength: Product count, marketing status distribution, submission activity
- Regulatory momentum: Submission types, approval pathway efficiency, recent activity
- Patent cliff analysis: Exclusivity timeline, generic entry risk, therapeutic equivalence codes
- Market positioning: Regulatory advantages, breakthrough designations, competitive moats
- Investment thesis: Risk-adjusted projections, catalyst timeline, downside protection
**Field Interpretation:**
- Marketing status: Prescription (active), Discontinued (off-market), OTC (over-counter)
- TE codes: AB (therapeutically equivalent), AP (pharmaceutical equivalent), etc.
- Submission types: Original NDA/BLA, Supplement, Amendment, Resubmission
- Submission class: Priority, Standard, Fast Track, Breakthrough Therapy
**Output Format:**
1. **Portfolio Overview** (table): Product count, marketing status, regulatory activity
2. **Competitive Moats** (3 bullets): Patent protection, regulatory barriers, market positioning
3. **Generic Competition Risk** (2 bullets): Current competitors, entry barriers
4. **Investment Thesis** (1 paragraph): Risk-adjusted projections with catalyst timeline and key risks
Execute each query sequentially and provide comprehensive FDA-focused market intelligence for investment decision-making combining regulatory pathway analysis, generic competition assessment, and patent protection evaluation.`;
// Build enhanced prompt with AI assistant guidance
const enhancedPrompt = this.buildEnhancedPrompt(
basePrompt,
this.getPrimarySearchType(),
this.getPromptSpecificExamples()
);
return this.createPromptResult(
`Enhanced FDA Market Intelligence for ${searchEntity}`,
enhancedPrompt
);
}
/**
* Get prompt-specific working examples for market intelligence
*/
protected getPromptSpecificExamples(): WorkingExample[] {
return [
{
name: "Company Portfolio Analysis",
description: "Analyze company's product marketing status distribution",
query: {
method: "lookup_drug",
search_term: "sponsor_name:\"PFIZER\"",
search_type: "general",
count: "products.marketing_status",
limit: 15
},
expectedFields: ["products.marketing_status"],
notes: "Shows portfolio health: Prescription vs Discontinued products"
},
{
name: "Regulatory Submission Activity",
description: "Assess company's regulatory pipeline and activity",
query: {
method: "lookup_drug",
search_term: "sponsor_name:\"PFIZER\"",
search_type: "general",
count: "submissions.submission_type",
limit: 10
},
expectedFields: ["submissions.submission_type"],
notes: "Indicates R&D momentum and regulatory engagement"
},
{
name: "Generic Competition Landscape",
description: "Count competitors in the same therapeutic area",
query: {
method: "lookup_drug",
search_term: "openfda.generic_name:\"atorvastatin\" AND products.marketing_status:Prescription",
search_type: "general",
count: "sponsor_name",
limit: 10
},
expectedFields: ["sponsor_name"],
notes: "Market concentration risk: fewer sponsors = higher market power"
},
{
name: "Therapeutic Equivalence Analysis",
description: "Check drug's therapeutic equivalence rating",
query: {
method: "lookup_drug",
search_term: "products.brand_name:\"LIPITOR\"",
search_type: "general",
limit: 1,
fields_for_general: "products.te_code"
},
expectedFields: ["products.te_code"],
notes: "TE codes indicate generic substitution potential and competitive protection"
}
];
}
/**
* Get the primary search type for this prompt
*/
protected getPrimarySearchType(): FdaSearchType {
return 'general';
}
}
