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Glama

Ensembl MCP Server

Server Configuration

Describes the environment variables required to run the server.

NameRequiredDescriptionDefault

No arguments

Schema

Prompts

Interactive templates invoked by user choice

NameDescription

No prompts

Resources

Contextual data attached and managed by the client

NameDescription

No resources

Tools

Functions exposed to the LLM to take actions

NameDescription
ensembl_feature_overlap

Find genomic features (genes, transcripts, regulatory elements) that overlap with a genomic region or specific feature. Automatically handles assembly-specific format variations (GRCh38/hg38, chromosome naming conventions, coordinate systems). Covers /overlap/region and /overlap/id endpoints.

ensembl_regulatory

Get regulatory features, binding matrices, and regulatory annotations. Covers regulatory overlap endpoints and binding matrix data.

ensembl_protein_features

Get protein-level features, domains, and annotations for proteins and translations.

ensembl_meta

Get server metadata, data releases, species info, and system status. Covers /info/* endpoints and /archive/id for version tracking.

ensembl_lookup

Look up genes, transcripts, variants by ID or symbol. Get cross-references and perform ID translation. Covers /lookup/* and /xrefs/* endpoints plus variant_recoder.

ensembl_sequence

Retrieve DNA, RNA, or protein sequences for genes, transcripts, regions. Covers /sequence/id and /sequence/region endpoints.

ensembl_mapping

Map coordinates between different coordinate systems (genomic ↔ cDNA/CDS/protein) and between genome assemblies. Covers /map/* endpoints.

ensembl_compara

Comparative genomics: gene trees, homology, species alignments, and evolutionary analysis. Covers /genetree/, /homology/, /alignment/* endpoints.

ensembl_variation

Variant analysis: VEP consequence prediction, variant lookup, LD analysis, phenotype mapping, haplotypes. Covers /variation/, /vep/, /ld/, /phenotype/ endpoints.

ensembl_ontotax

Ontology term search and NCBI taxonomy traversal. Search GO terms, phenotype ontologies, and taxonomic classifications.

MCP directory API

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