"A database of diseases with associated genetic variants and sequencing information" matching MCP tools:

• gene_diseases

  Hpo Api

  "What diseases is gene [NCBIGene:N] associated with" / "diseases linked to gene [X]" / "TP53 disease associations" — fetch diseases associated with a gene ID (NCBIGene:N format). Use for gene-to-disease lookups in rare-disease research, variant prioritization. Example ID: NCBIGene:7157 (TP53).

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• get_genetic_variants

  Health Data

  Search ClinVar for genetic variants associated with a gene. Get clinical significance, conditions, and review status from NCBI ClinVar.

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• gene_to_disease

  Monarch Initiative

  Diseases associated with a gene (NCBIGene:… or HGNC:… id).

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• get_product_details

  SendaMeal Storefront

  Get product details (variants, options and images) by product ID(s). Arguments: productIds - array of product IDs to get details for (from 'search_products'). [IMPORTANT] Request only the products the user needs. A server-configured limit applies (default 20); requests over the limit are rejected with an error (retry with fewer IDs). option_values - resolve a specific variant by option/value IDs. Only valid with a SINGLE productId, and applied on the B2C storefront catalog. B2B buyers instead receive every variant (each with its option/value IDs) and pick the desired one from the returned list. channelId - optional; scopes the B2B catalog. Defaults to the channel resolved from the request. Returns: - products: array of products, each with: - variants: each carrying entityId, SKU, and options (optionId, optionLabel, valueId, valueLabel). - For B2B buyers, variants also include price, inventoryLevel, purchaseable, and bulkPricing. - Products not found are omitted from the array. Flow: - Call 'search_products' to get product IDs. - Call this tool with the product IDs to get variants, options and images. - Call 'add_item_to_cart' with results of 'search_products' and 'get_product_details' (variant) tools. - [IMPORTANT] If a product has variants you must specify which variant to add.

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• fda_save_aliases

  FDA Data MCP

  Save normalized alias names for a parent company, updating confidence and tracking collisions. Use this for true name variants of the same company record. If a collision says the alias already belongs to another company_id, use fda_link_subsidiaries instead of forcing the alias. Typical workflow: call fda_suggest_subsidiaries first, review results, then call this tool with confirmed same-entity alias names.

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• ask

  sniff-mcp

  Ask Sniff a natural-language canine-genetics question and get a GROUNDED, CITED answer (or an honest abstain). Covers inherited diseases (OMIA) and their human homologs (the dog<->human disease bridge), breed disease/carrier risk, variant pathogenicity grades (AVCG; Boeykens et al. 2024, curated in OMIA), longevity/life-expectancy (McMillan 2024), temperament (Darwin's Ark/Morrill 2022, with breed-explains-X% caveats), and genetic diversity. The engine answers ONLY from cited Sniff atoms and returns `abstained: true` if it lacks grounded data — it never guesses. Educational, not diagnostic (carrier != affected; advise a vet). Returns {answer, citations:[atom_ids], abstained}. USE THIS for any 'what is X / does breed Y get Z / human equivalent of W' question; use the variant/breed/gene tools for structured lookups by identifier.

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• lookup_health_fact

  Uphealth Signal

  Zero setup — NO key required. Returns ONE already-public federal health fact, list, or tip for a question or topic (e.g. "high blood pressure", "sleep", "type 2 diabetes"), with its federal source (CDC / MedlinePlus / NIH) and a link to the public uphealth.me page. Free + rate-limited. For adaptive, patient-specific message sequencing — receptivity-scored cues + audience-safety verdicts over the full library of federally-sourced facts, lists & tips — get a free Discovery key at https://uphealth.us/signup

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• gnomad_get_variant

  gnomad-genetics-mcp-server

  Fetch the full gnomAD population record for one or more variants — allele count/number/frequency overall and broken down per genetic-ancestry group, homozygote and hemizygote counts, quality flags, transcript consequence, in-silico predictor scores, and joined ClinVar clinical significance. The "how common, is it benign" answer in one call. Accepts a batch of up to 25 IDs (chrom-pos-ref-alt or rsID) with per-item partial success: a malformed or absent ID lands in failed[] without failing the others. An empty found[] for a well-formed ID means the variant is not in the chosen dataset — pair with gnomad_get_coverage to confirm the position is callable before concluding true absence. Data source: gnomAD (Broad Institute) — https://gnomad.broadinstitute.org/

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• string_proteins_for_term

  STRING Database MCP Server

  Retrieve proteins annotated with a functional term or descriptive text in a single species. You can query for tissues, compartments, diseases, processes, pathways, and domains. IMPORTANT: For cross-species comparisons, run this tool separately for each species. Select relevant model organisms to search or ask user to provide the selection. The results reflect annotation depth within each category; use caution when interpreting. If no results are found, try simplifying the query. For tissue queries, follow BRENDA tissue nomenclature and omit the word "tissue" (e.g. use "skin" instead of "skin tissue"). Output fields: - category: Source database of the matched functional term (e.g. GO, KEGG, Reactome, Pfam, InterPro). - term: Exact identifier for the functional term. - description: The free text description of the term. - proteinCount: Number of proteins annotated with that term - preferredNames: Full protein-name list when `detail_for_term` is set - stringIds: STRING protein identifiers when returned - preferredNames_omitted: True when a row omits the protein-name list - stringIds_omitted: True when STRING identifiers are omitted

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• federation_catalog_search_grouped_multi

  ComOS Federation

  Search product FAMILIES (variants of the same product grouped together) across multiple tenants in parallel. Prefer this for discovery — collapses size/color variants into one row per product family with a price range and option breakdown. Use federation_catalog_search_multi when you need exact variant SKUs. tenant_ids come from federation_list_tenants (or pass "all"). Public read — auth_token is optional. Returns: { results: [{ tenant_id, status, data?, error? }], summary: { total_tenants, succeeded, failed } } — per-tenant data is grouped families with priceRange, variantCount, options, and nested variants. Example: call federation_catalog_search_grouped_multi with arguments {"tenant_ids":"<tenant_ids>","query":"<query>"}.

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• uniprot_get_entry

  uniprot-mcp-server

  Fetch full curated UniProtKB entries by accession in one batch (up to 20). Each entry carries function, catalytic activity, cofactors, subcellular location, disease involvement, PTMs, natural variants, isoforms, domains, GO terms, keywords, and cross-references. Partial failures do not abort the batch — resolved entries land in succeeded[] and unknown/withdrawn accessions in failed[]. Pass fields to trim the upstream projection. A single oversized record returns kind: "outline" (a section listing with byte sizes) instead of overflowing context — re-call the same accession with sections:[...] (e.g. ["disease","variants"]) to pull only those. This tool does not search: accessions come from uniprot_search_proteins.results[].accession or uniprot_map_ids. Strip any isoform suffix (P04637-2 to P04637) before calling.

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• resize_database

  Dockhold

  Change how much memory an app's managed database gets. Call this when the database is slow or out of memory. db_ram_mb must be one of the sizes get_resource_usage reports under db_ram.steps_mb and fit your database-RAM pool. WARNING: the database restarts briefly to apply the new size, so the app loses its database connection for a few seconds. Only works if the app has a managed database.

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• arena_get_strategy_insights

  Backtesting Arena

  Which strategy and interval combinations actually performed? Aggregated backtest performance per (strategy × interval) cell. If `strategy` AND `interval` provided, returns detail with per-asset breakdown + param variants. Otherwise returns the matrix. Free tier is limited to the same strategies that are free in the backtester itself (rsi_sma, golden_cross, rsi_ob_os, bnh_fixed, dca_reference); the response then carries `plan_capped: true` plus `plan_cap_note`, so a short matrix is never mistaken for a thin database. Detail mode on a Pro-only strategy returns 403 rather than a silently empty answer. API Pro and Power receive every cell. [Free: 5 strategies / Pro+: full]

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• get_skill

  API Direct

  Get a ready-made skill's step-by-step playbook with your inputs filled in, then follow it. Returns an ordered recipe of tool calls to execute. PREFER running a matching skill over improvising raw searches — skills encode the filters and sequencing that produce far better results. If the user names a skill (e.g. "use the local-buying-intent-capture skill"), pass that as skill_id directly; otherwise call list_skills first to find the right id.

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• lookalike_domains

  Dechonet-MCP

  Generate the typosquat/lookalike variants of a domain that phishers actually register — homoglyph swaps (l→1, o→0, rn→m), TLD swaps (.com→.co), character omissions, transpositions, repetitions, hyphenations — and check which of them are currently registered (live NS delegation via DoH). Use this to assess brand-impersonation and phishing exposure for a domain the user is responsible for. A registered variant is NOT proof of abuse (it may be an unrelated legitimate site) — follow up with whois_lookup on each hit for its owner and registration date. Read-only; requires no API key; rate-limited. Returns generated/checked counts and the registered variants with the technique that produced each.

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• search

  Opentargets

  "Find [disease / drug / gene target]" / "Open Targets lookup for [name]" / "what's the Open Targets ID for [X]" — text search across diseases, drug targets, and drugs in the Open Targets Platform (the leading drug-discovery knowledge graph). Returns ranked matches with their canonical IDs (ENSG... for targets, EFO_... for diseases, CHEMBL... for drugs). Use first to find IDs, then call target/disease/drug for details.

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• get_provisional_mortality

  CDC Mortality (WONDER)

  Get most recent provisional mortality data including COVID and other causes. Returns provisional death counts from the NVSS, covering major cause groups including COVID-19, respiratory diseases, circulatory diseases, and more. Data is updated weekly and covers the most recent periods. Args: state: Filter by state/jurisdiction name (e.g. 'New York', 'Florida'). Case-insensitive. Returns all jurisdictions if not specified. cause_group: Filter by cause group (e.g. 'COVID-19', 'Respiratory', 'Circulatory', 'Malignant neoplasms'). Partial match supported. Returns all cause groups if not specified. limit: Maximum number of records to return (default 50, max 1000).

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• children

  Mitre Cwe

  "CWEs derived from / under [N]" / "child weaknesses of [CWE]" / "more specific variants of [X]" — list immediate children of a CWE in the relationship tree. CWE is hierarchical; e.g. children of CWE-119 (memory bounds) include CWE-787 (out-of-bounds write) and CWE-125 (out-of-bounds read).

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• query

  Myvariant

  Search aggregated human genetic-variant annotations on MyVariant.info. Accepts an rsID ("rs58991260"), an HGVS id ("chr1:g.218631822G>A"), or a fielded query ("dbnsfp.genename:CDK2", "clinvar.rcv.clinical_significance:pathogenic"). Each hit merges dbSNP, ClinVar clinical significance, CADD/dbNSFP deleteriousness scores, and gnomAD population allele frequencies. Returns { total, hits }; hit._id is usually the HGVS id you can pass to the variant tool.

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• get_product

  Synchronity

  Retrieve detailed information about a specific product including variants, pricing, images, and availability. May also return `addons` — customer-selectable options defined by the store (e.g. engraving, gift wrap, size add-ons). When a product has addons, present them to the buyer and collect every addon with `required: true` before calling add_to_cart; for any option carrying a `price_modifier`, show that surcharge so the buyer knows the added cost. The card already shows the product details to the user, so keep your text reply brief and do not re-describe what the card displays.

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