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20 Best PostgreSQL MCP Servers: compared and ranked, October 2026Ranked from 1,280 matching servers on stars, growth, downloads and maintenance. Updated .

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  • A
    license
    B
    quality
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    maintenance
    Provides seamless access to UniProtKB protein database, enabling queries for protein entries, sequences, Gene Ontology annotations, full-text search, and ID mapping across 200+ database types.
    5
    16 PyPI
    2
    MIT
  • F
    license
    B
    quality
    D
    maintenance
    A comprehensive Model Context Protocol (MCP) server for accessing the STRING protein interaction database. This server provides powerful tools for protein network analysis, functional enrichment, and comparative genomics through the STRING API.
    6
    4
    -
  • A
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    B
    quality
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    Enables comprehensive access to PubChem's chemical database with over 110 million compounds. Supports chemical searches, structure analysis, bioactivity data, safety information, and molecular property calculations through 30 specialized tools.
    30
    MIT
  • A
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    Not graded
    quality
    B
    maintenance
    Enables AI agents to search and retrieve compounds, drugs, diseases, pathways, genes, enzymes, glycans, modules, and KO entries; fetch full parsed flat-file entries by ID; and list database contents through keyless REST tools.
    362 npm
    MIT
  • A
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    quality
    B
    maintenance
    Enables AI agents to query the PomBase fission yeast model-organism database for genetic and molecular data through the Pipeworx MCP gateway.
    1 npm
    MIT
  • A
    license
    Not graded
    quality
    C
    maintenance
    MCP server that exposes STRING database functionality, allowing AI agents to resolve protein identifiers, retrieve interaction networks, perform homology lookups, and run functional enrichment analysis.
    7
    MIT
  • A
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    Not graded
    quality
    B
    maintenance
    Enables users to look up yeast genes/loci, search genes and alleles by free text, and retrieve Gene Ontology annotations from the Saccharomyces Genome Database.
    307 npm
    MIT
  • A
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    Not graded
    quality
    A
    maintenance
    Enables looking up genes, fetching sequences, predicting variant consequences, finding orthologs, and cross-database xrefs via Ensembl REST API through MCP.
    431 npm
    3
    Apache 2.0
  • A
    license
    Not graded
    quality
    B
    maintenance
    Enables querying metadata from MyVariant.info, a comprehensive variant annotation database, providing dataset statistics, source information, and build versions.
    1 npm
    MIT
  • A
    license
    Not graded
    quality
    B
    maintenance
    Enables AI agents to look up molecular interactions from the EBI IntAct database by gene/protein name or UniProt ID, returning detection method, interaction type, organism, PubMed reference, and MI confidence score, along with fast interaction counts. It is keyless and available either through a hosted MCP endpoint, a plain HTTP API, or a local stdio server.
    322 npm
    MIT
  • A
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    Not graded
    quality
    C
    maintenance
    Enables querying the BOLD Systems global DNA barcode database for specimen records, taxonomy, barcode sequences, and BIN clusters, with keyless access and FASTA-ready output.
    MIT
  • A
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    Not graded
    quality
    D
    maintenance
    An MCP server that enables language models to fetch protein information from the UniProt database, including protein details, sequences, functions, and structures.
    MIT
  • A
    license
    Not graded
    quality
    A
    maintenance
    A unified biomedical graph database that integrates 50+ primary data sources — genes, proteins, compounds, diseases, pathways, and clinical data — into a single queryable graph with billions of cross-reference edges. Its native MCP server gives LLMs direct access to structured, authoritative biomedical data, complementing their reasoning with reliable identifiers and up-to-date database content.
    20
    AGPL 3.0