"How to run a Python file using Claude Desktop" matching MCP servers:

Enables Claude Code to send prompts to Claude Desktop using macOS automation and AppleScript. Supports conversation management and configurable response polling, though reading responses back is limited by Electron's accessibility APIs.

MCP server that fixes Windows DPI coordinate scaling for AI desktop automation. Provides UI element finding via Windows Accessibility APIs and coordinate conversion between physical and logical coordinate systems.

MCP server for controlling a transparent sci-fi cockpit overlay on your desktop, allowing AI agents to spawn, move, configure, and close holographic widgets (clock, system stats, map, etc.) via MCP.

Enables supervised, visible control of a Windows desktop from an MCP client, providing real mouse and keyboard input, screenshots, local safety controls, and a teaching mode for guidance without injection.

Adds automation capabilities to Claude Desktop through MCP and enables Claude Desktop to act as a model gateway for Claude Code, solving WSL-Windows integration challenges through file-based bidirectional communication.

Enables AI assistants to capture and analyze screen content across multi-monitor setups with smart image optimization. Provides screenshot capabilities and detailed monitor information for visual debugging, UI analysis, and desktop assistance.

Enables AI clients to control the Windows NetEase Cloud Music desktop app via local stdio MCP, including reading current song and liked state, searching and playing tracks, playback control, track skipping, and setting the current song's liked status.

Enables AI assistants to read and send WhatsApp messages on Windows through the official WhatsApp Desktop application using Edge WebView2 CDP automation.

Enables merging multiple files into a single file through a simple MCP interface. Provides a secure way to combine files while restricting access to only allowed directories.

An MCP server that provides Claude with comprehensive desktop automation capabilities including browser control, window management, and native mouse/keyboard input on Windows. It enables users to capture screenshots, launch applications, and interact with the system clipboard through natural language.

A powerful, security-hardened MCP server for intelligent file organization. Provides high-level atomic tools for organizing files into categories, detecting duplicates, extracting EXIF/ID3 metadata, scheduling automatic organization, and more — for use with Claude, Cursor, and Gemini CLI.

Exposes your project's package.json scripts as MCP tools, allowing AI assistants to discover and execute npm/yarn/pnpm/bun scripts directly. Automatically detects your package manager and enables running scripts with optional arguments through natural language commands.

GNOME desktop automation for AI agents. 30 tools via D-Bus: screenshots, window management, mouse/keyboard injection, clipboard, workspaces, and system notifications. Works on any GNOME 45–49 Linux desktop.

Enables comprehensive Trello integration through Claude Desktop, allowing users to search, create, update, and manage Trello boards, cards, lists, comments, and collaborate with team members through natural language.

A desktop MCP service that integrates voice assistants into Mac workflows, enabling Obsidian memory, app control, Claude Code sessions, pending actions, and multi-language HTTP access.

Python MCP server for SolidWorks automation with 109 tools covering the full CAD lifecycle. Enables AI-assisted design workflows through COM automation on Windows.

Enables high-speed native macOS automation for Claude by interacting directly with the Accessibility API, AppleScript, and UI trees instead of using screenshots. It allows users to read app states, click elements, and type text semantically across any macOS application.

Enables safe Windows desktop automation and computer use through natural language, including window observation, UI Automation, and execution of verified actions like clicking, typing, and scrolling.

A production-oriented MCP server that exposes task-level WeChat Desktop automation to AI clients, enabling status checks, message fetching/reply, contact addition, and Moment publishing on macOS via accessibility automation.

Enables secure, deny-by-default automation of Windows windows with per-action permissions, allowing observation, clicking, typing, and dragging on approved applications while verifying target identity and focus at runtime.