reactome-mcp
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- AlicenseNot gradedqualityCmaintenanceEnables AI agents to query the Reactome biological pathway knowledge-base for pathways, participants, and orthologous events using natural language.5 npmMIT

reactome-mcpofficial
AlicenseBqualityDmaintenanceEnables AI assistants to search, browse, analyze, and export biological pathway data from Reactome through natural language.566Apache 2.0- AlicenseNot gradedqualityCmaintenanceEnables AI agents to query the WikiPathways open community pathway database via natural language, part of the Pipeworx MCP gateway.2 npmMIT
- AlicenseNot gradedqualityDmaintenanceEnables AI agents to query clinical genomics databases, retrieve supporting literature, analyze population genetics, and visualize biological pathways.18MIT
- FlicenseNot gradedqualityDmaintenanceEnables natural language querying and analysis of KEGG biological databases, including pathways, genes, compounds, reactions, diseases, and drugs.11-
- AlicenseAqualityBmaintenanceEnables unified access to 110 life science APIs and databases, including genomics, proteomics, chemistry, literature, and clinical data. Users can query genes, proteins, compounds, pathways, and more through natural language.3MIT
TDQS
Scored across 17 tools
Each tool targets a distinct resource and action, from listing species and diseases to fetching entries, exports, and analysis. The only slight overlap between get_event_sbml and download_export is clearly delineated by inline vs. file output, so an agent can reliably select the right tool.
All tool names follow a consistent verb_noun snake_case pattern (e.g., list_diseases, get_analysis_results, find_pathways_for_entity). Even compound names like get_analysis_not_found maintain the convention, with no camelCase or varied verb styles.
At 17 tools, the set is slightly above the typical 3-15 range but well-scoped for Reactome's broad functionality. The tools cover searching, browsing, exporting, and analysis without redundancy, so the count feels justified rather than excessive.
The tool surface covers core Reactome operations: browsing pathways and entities, searching, exporting in multiple formats, and performing over-representation analysis. Minor gaps exist, such as no direct tool for species-wide reaction lists or advanced API features, but agents can work around these with existing tools.