reactome-mcp
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- AlicenseNot gradedqualityBmaintenanceEnables AI agents to query the Reactome biological pathway knowledge-base for pathways, participants, and orthologous events using natural language.404 npmMIT

reactome-mcpofficial
AlicenseBqualityCmaintenanceEnables AI assistants to search, browse, analyze, and export biological pathway data from Reactome through natural language.56255 npm6Apache 2.0- AlicenseNot gradedqualityBmaintenanceEnables AI agents to search and retrieve compounds, drugs, diseases, pathways, genes, enzymes, glycans, modules, and KO entries; fetch full parsed flat-file entries by ID; and list database contents through keyless REST tools.362 npmMIT
- AlicenseNot gradedqualityBmaintenanceEnables AI agents to query the WikiPathways open community pathway database via natural language, part of the Pipeworx MCP gateway.398 npmMIT
- AlicenseNot gradedqualityDmaintenanceEnables AI agents to query clinical genomics databases, retrieve supporting literature, analyze population genetics, and visualize biological pathways.18MIT
- FlicenseNot gradedqualityDmaintenanceEnables natural language querying and analysis of KEGG biological databases, including pathways, genes, compounds, reactions, diseases, and drugs.11-
TDQS
Scored across 17 tools
Each tool targets a distinct resource and action, from listing species and diseases to fetching entries, exports, and analysis. The only slight overlap between get_event_sbml and download_export is clearly delineated by inline vs. file output, so an agent can reliably select the right tool.
All tool names follow a consistent verb_noun snake_case pattern (e.g., list_diseases, get_analysis_results, find_pathways_for_entity). Even compound names like get_analysis_not_found maintain the convention, with no camelCase or varied verb styles.
At 17 tools, the set is slightly above the typical 3-15 range but well-scoped for Reactome's broad functionality. The tools cover searching, browsing, exporting, and analysis without redundancy, so the count feels justified rather than excessive.
The tool surface covers core Reactome operations: browsing pathways and entities, searching, exporting in multiple formats, and performing over-representation analysis. Minor gaps exist, such as no direct tool for species-wide reaction lists or advanced API features, but agents can work around these with existing tools.