List alternate gene symbols and database cross-references for a target.

List diseases linked to a target with association scores.

List available chemical probes and their quality metrics.

Return ChEMBL target class annotations for a gene.

Fetch DepMap CRISPR essentiality scores across cell lines.

Return RNA and protein expression profiles for a target across tissues.

Fetch genetic constraint metrics (gnomAD) for a target.

Return cancer hallmark annotations associated with a target.

Retrieve cross-species homologues for a target gene.

Retrieve core identity details for a target gene.

Retrieve protein interaction partners for a target from curated databases.

Return compounds with known activity on the target.

Return literature co-occurrence records for a target.

Retrieve mouse knockout phenotypes associated with a target.

List pathway memberships and Gene Ontology annotations for a target.

Return target prioritisation scores compiled across data sources.

Retrieve documented safety liabilities for a target.

Return subcellular localisation annotations for a target.

Fetch Target Enabling Package (TEP) information for a gene.

Return tractability assessments across modalities for a target.

List targets associated with a disease, including evidence scores.

Retrieve core metadata for an Open Targets disease entity.

Retrieve drugs with investigational or approved indications for a disease.

Return literature co-occurrence records mentioning a disease.

Retrieve ontology structure for a disease including parents, children, and ancestors.

List Open Targets Associated Research (OTAR) projects linked to a disease.

Fetch HPO phenotype annotations linked to a disease.

Find semantically similar diseases based on PubMed embeddings.

Retrieve adverse event signals associated with a drug.

Retrieve cross-database identifiers related to a drug.

Fetch identity, indication, and mechanism data for a drug.

List diseases connected to a drug across indications and mechanisms.

Return targets linked to a drug via mechanism-of-action data.

Return literature co-occurrence records mentioning a drug.

Retrieve pharmacogenomics data linking genetic variants to drug response.

Summarise high-level pharmacovigilance data for a drug.

Find semantically similar drugs based on PubMed embeddings.

Fetch detailed regulatory warnings, including withdrawals and boxed labels.

Inspect evidence for biomarker annotations linking a target and disease.

Retrieve evidence strings linking a target to a disease.

Identify targets with similar association profiles to the seed target.

Search Open Targets entities and resolve synonyms to canonical IDs.

Return facet counts to help filter search results.

Return autocomplete suggestions for partially typed queries.

List credible sets that include a specific variant.

Retrieve evidence strings linking a variant to targets or diseases.

Retrieve core metadata and functional annotations for a variant.

Retrieve enhancer-to-gene (E2G) predictions overlapping a variant.

Retrieve pharmacogenomic annotations for a variant.

Retrieve protein-level consequences for a variant.

Fetch detailed information for a specific study locus credible set.

Retrieve colocalisation results for a credible set.

Query credible sets with flexible filtering options.

List studies linked to one or more diseases.

Retrieve fine-mapped credible sets for a study.

Retrieve metadata and cohort details for a GWAS study.

Return Open Targets Platform release metadata.

List sources contributing target–disease association evidence.

Retrieve multiple diseases in a single request.

Retrieve multiple drugs in a single request.

Resolve Gene Ontology identifiers to human-readable labels.

Enumerate interaction databases integrated into Open Targets.

Retrieve multiple targets in a single request.

Map free-text terms to canonical Open Targets identifiers.

Execute one GraphQL query against many variable sets.

ADVANCED: Execute a raw GraphQL query against Open Targets.

ADVANCED: Return the GraphQL schema in SDL format.

Find repurposing candidates by chaining disease, target, and drug evidence.