heor-agent-mcp

Search PubMed, ClinicalTrials.gov, bioRxiv/medRxiv, ChEMBL, FDA Orange Book, FDA Purple Book, enterprise sources (Embase, ScienceDirect, Cochrane, Citeline, Pharmapendium, Cortellis), HTA cost reference sources (CMS NADAC, PSSRU, NHS National Cost Collection, BNF, PBS Schedule), LATAM sources (DATASUS, CONITEC, ANVISA, PAHO, IETS, FONASA), APAC sources (HITAP), and HTA appraisal/guidance sources (NICE TAs, CADTH CDR/pCODR, ICER, PBAC PSDs, G-BA AMNOG, HAS Transparency Committee, IQWiG, AIFA, TLV Sweden, INESSS Quebec) for evidence on a drug or indication. Returns structured results including HTA precedents and appraisal decisions with a full audit trail suitable for HTA submissions.

Build a cost-utility analysis (ICER, QALY, PSA, sensitivity analysis) for a drug vs comparator. Follows ISPOR good practice guidelines and NICE reference case. Includes probabilistic sensitivity analysis (PSA), one-way sensitivity, and cost-effectiveness acceptability curve (CEAC).

Structure evidence into HTA body-specific submission format (NICE STA, EMA, FDA, IQWiG, HAS, EU JCA). Produces draft sections with gap analysis. Accepts output from literature_search and cost_effectiveness_model.

Search a project's knowledge base (raw/ and wiki/) for text matches. Returns file paths with line numbers and snippets. Use this to find previously-retrieved literature, model runs, and compiled wiki content without re-querying external APIs.

Read a file from a project's raw/ or wiki/ tree. Path is relative to project root. Only raw/ and wiki/ subtrees accessible.

Write a file to the project's wiki/ tree. Path MUST start with 'wiki/' and end with '.md'. Use this to compile/organize evidence from raw/ files into a structured knowledge base. Supports Obsidian-style [[wikilinks]].

Initialize a new HEOR project workspace with directory skeleton and project.yaml metadata. Idempotent — returns existing project if already created. Required before using the project parameter in other tools.