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search_grounded_evidence

Searches PubMed for mechanistic evidence to answer clinical, pharmacological, or mechanistic questions. Returns an evidence projection with novelty verdicts, entailment grades, and contradictions.

Instructions

Look up PubMed-grounded mechanistic evidence for ANY clinical, pharmacological, or mechanistic question (utility / fallback tool — a lighter-weight sibling of generate_experiment, not limited to any one domain).

ASYNC (submit + poll): runs the SAME full TransBench pipeline as generate_experiment (not a separate, cheaper retrieval path), so it is just as slow (~60-120s) and is likewise non-blocking — it STARTS the run and returns a job handle immediately. You MUST then poll get_experiment_result(job_id) until status is "done"/ "error". On "done", result is the smaller, evidence-focused projection: for each hypothesis its novelty verdict and every retrieved evidence item (each with a resolvable citation, an entailment verdict, and an evidence grade), plus the deduplicated reference list, any contradictions surfaced, and the uncertainty note. Omits axes/ top_experiment/run_manifest.

Args: question: A free-text clinical/pharmacological/mechanistic question (3-8000 characters), any domain.

Returns: Immediately: {"job_id", "status": "running", "poll_tool": "get_experiment_result", "message"}. Poll get_experiment_result(job_id) — on "done" its result is the grounded-evidence projection (carrying the fixed research-only disclaimer), on "error" its result is {"error", "message", "status_code"}. Obviously invalid input is rejected inline (no job).

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
questionYes

Output Schema

TableJSON Schema
NameRequiredDescriptionDefault

No arguments

Behavior5/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

With no annotations provided, the description fully bears the transparency burden. It discloses async behavior, approximate runtime (60-120s), non-blocking nature, and exactly what the final result contains (novelty verdict, evidence items, citations, contradiction, etc.). It also explains error handling for invalid input. This is exceptionally transparent.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness4/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is well-structured with clear sections: first line states purpose, then async behavior, then parameter details, then return format. While it is slightly verbose, every sentence adds value. It is front-loaded with the main purpose, aiding quick comprehension.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness4/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

Given the tool's complexity (async, long-running, sibling tool comparison), the description covers most key aspects: purpose, usage, parameter constraints, return format (including error handling and disclaimer). It does not mention rate limits or authentication, but those are not critical for understanding how to use the tool.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters4/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

The input schema has 0% description coverage, so the description must add meaning for the single parameter `question`. It adds character length (3-8000), domain scope (clinical/pharmacological/mechanistic), and type (free-text). This provides useful constraints beyond the schema's bare type definition.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly states the tool's verb ("Look up"), resource ("PubMed-grounded mechanistic evidence"), and scope (any clinical/pharmacological/mechanistic question). It distinguishes itself from sibling `generate_experiment` by being lighter-weight and a fallback tool, and even notes it is not limited to any one domain, providing strong purpose clarity.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines4/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

The description provides explicit guidance on when to use (any question) and how to use (async submit+ poll, must poll `get_experiment_result`). It also compares to `generate_experiment`. However, it does not explicitly state when not to use this tool, such as when full experiment details are needed, though this is implied by the omission list.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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