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Resolve HPO Cross-Reference

resolve_xref
Read-onlyIdempotent

Resolve an external cross-reference CURIE (e.g., UMLS, SNOMED CT) to the HPO terms that map to it. Supports pagination for large result sets.

Instructions

Resolve an external cross-reference CURIE (UMLS/SNOMEDCT_US/NCIT/MEDDRA/ICD-10/ICD-9/MONDO/DOID/ORPHA) back to the HPO term(s) that cross-reference it. Returns matches[] plus a pagination block {total, returned, limit, offset, truncated, next_offset}; when truncated, next_commands carries a forward-page step (offset). Signature: resolve_xref(xref_id, limit=, offset=, response_mode=).

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
limitNoMax matches (default 25).
offsetNoRows to skip for forward paging (default 0).
xref_idYesAn external cross-reference CURIE (prefix:local), e.g. UMLS/SNOMED/NCIT/MEDDRA, to resolve back to the HPO term(s) that cross-reference it.
response_modeNoVerbosity: minimal|compact|standard|full (default compact).compact

Output Schema

TableJSON Schema
NameRequiredDescriptionDefault
hintNo
_metaNo
fieldNo
limitNo
totalNo
offsetNo
matchesNo
messageNo
successNo
xref_idNo
returnedNo
retryableNo
truncatedNo
candidatesNo
error_codeNo
hpo_versionNo
next_offsetNo
allowed_valuesNo
recovery_actionNo
Behavior4/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations already declare the tool as read-only, idempotent, and non-destructive. The description adds value by detailing the response structure (matches plus pagination), pagination behavior with 'next_commands', and the function signature. No contradictions.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is concise (two sentences), with the first sentence clearly stating purpose and the second adding critical pagination and signature details. No redundant information.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness5/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

Given the presence of an output schema, the description adequately explains the return structure and pagination. For a lookup tool with good annotations, this is complete and sufficient.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema coverage is 100% with good descriptions for all four parameters. The description adds a function signature listing parameters and mentions pagination, but does not substantially enhance understanding beyond the schema. Baseline 3 is appropriate.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly defines the tool's purpose: resolving external cross-reference CURIEs to HPO terms. It lists supported prefixes (UMLS, SNOMEDCT_US, etc.) and distinguishes this tool from siblings like 'resolve_term' which likely handles HPO IDs, and 'map_cross_ontology' which maps between ontologies.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines4/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

The description implies usage when an external ID needs to be mapped to HPO terms, but does not explicitly state when not to use it or mention alternatives like 'resolve_term' or 'map_cross_ontology'. The guidance is clear but lacks exclusion criteria.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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