Resolve one supported GRCh38 germline variant and return structured, source-backed ACMG/AMP evidence with provenance and explicit limitations. The public server is read-only and intended for professional review.
Provides a programmatic interface to the Genome Aggregation Database (gnomAD) API across versions v2.1.1, v3.1.2, and v4.1.0. It enables users to query gene metadata, variant information, population frequencies, and ClinVar data through a unified schema.
Look up variant allele frequencies by ancestry, gene loss-of-function constraint, gene variant lists, and sequencing coverage over gnomAD — with ClinVar significance joined in — via MCP.
Provides interpretable variant effect predictions for 4.2 million ClinVar variants using the EVEE API. Enables searching, comparing, and analyzing genetic variants with AI-generated mechanistic interpretations and disruption profiles.
