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query_clinvar

Query ClinVar for a variant's clinical significance, including pathogenicity, associated phenotypes, and review status (star rating).

Instructions

Look up ClinVar clinical significance for a variant. Shows pathogenicity classifications, associated phenotypes, and review status (star rating).

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
rsidYesdbSNP rsID
Behavior3/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Describes the outputs but does not disclose potential issues like network dependency, rate limits, or handling of variants not in ClinVar. Since no annotations are provided, the description bears full burden but is somewhat incomplete.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

Two sentences, no superfluous words. Purpose stated upfront, then specifics. Highly efficient.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness4/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

Given one parameter with full schema coverage and no output schema, the description sufficiently explains what the tool does and returns. Lacks minor behavioral details but adequate for a simple lookup.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema provides full coverage (rsid described). Description adds no extra meaning beyond what the schema says. Baseline 3 is appropriate.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

Clearly states the action ('Look up'), the resource ('ClinVar clinical significance for a variant'), and what it provides ('pathogenicity classifications, associated phenotypes, review status'). Distinct from sibling tools that query other databases.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines3/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

No explicit when-to-use or when-not-to-use guidance. Implies usage for variants with rsID, but does not mention alternatives or prerequisites.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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