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foldseek_search_structure

Search protein structure databases using a PDB or mmCIF query to find homologous structures based on fold similarity.

Instructions

Run FoldSeek easy-search with a PDB/mmCIF structure query.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
evalueNo
threadsNo
use_gpuNo
databaseNoafdb_uniprot50_minimal
max_hitsNo
query_pathYes
sensitivityNo
output_modesNo
alignment_typeNo
timeout_secondsNo

Output Schema

TableJSON Schema
NameRequiredDescriptionDefault

No arguments

Behavior2/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

With no annotations, the description should disclose behavioral traits. It mentions 'easy-search' but does not explain the computational cost, GPU usage, or what the tool does beyond a vague term.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness3/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is very concise with one sentence, but it sacrifices necessary detail. It is not verbose but is underinformative.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness1/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

Given the tool's complexity (10 parameters, no annotations, output schema), the description is severely incomplete. It fails to cover purpose relative to siblings, parameter meanings, or behavioral context.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters1/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema description coverage is 0%, yet the description adds no explanation for any of the 10 parameters. Parameters like evalue, sensitivity, and alignment_type are left completely unexplained.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose4/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly states the verb 'Run' and the resource 'FoldSeek easy-search with a PDB/mmCIF structure query'. However, it does not explicitly distinguish from the sibling tool foldseek_search_sequence which uses a sequence query.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines2/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

No guidance is provided on when to use this tool versus alternatives like foldseek_search_sequence or prerequisites such as needing a valid PDB file.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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