ClinicalTrials.gov MCP Server

# Example: Searching for Clinical Studies This example demonstrates how to use the `clinicaltrials_search_studies` tool to find clinical trials based on specific criteria. ## Example 1: Basic Search ### Tool Call ```json { "query": "cancer immunotherapy", "pageSize": 5 } ``` ### Tool Response ``` Found 5 studies of 7659 total (more pages available) • NCT06843551: The Miami "EMPIRE" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation Status: RECRUITING • NCT07032129: Sequential CAR-T Cells Targeting BCMA/GPRC5D in Patients With Relapsed/ Refractory Multiple Myeloma Status: RECRUITING • NCT00569231: Study With Candida Antigen for Treatment of Warts Status: COMPLETED • NCT05255302: De-escalation Immunotherapy mAintenance Duration Trial for Stage IV Lung Cancer Patients With Disease Control After Chemo-immunotherapy Induction Status: RECRUITING • NCT00285428: Study of hA20 (Humanized Anti-CD20) in Patients With CD20+ Non-Hodgkin's Lymphoma Status: COMPLETED Next page token: ZVNj7o2Elu8o3lpiC82t5qr-mpOQJJxmYPap ``` --- ## Example 2: Advanced Search with Filters ### Tool Call ```json { "query": "diabetes", "filter": "AREA[OverallStatus]RECRUITING AND AREA[Phase]PHASE3", "pageSize": 10, "sort": "EnrollmentCount:desc" } ``` ### Tool Response ``` Found 10 studies of 186 total (more pages available) • NCT06292013: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a) Status: RECRUITING • NCT05754957: A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome Status: RECRUITING • NCT07037433: Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity Status: RECRUITING • NCT07064473: A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease Status: RECRUITING • NCT06531824: EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin) Status: RECRUITING ...and 5 more Next page token: ZVNj7o2Elu8o3lpiC82t5qr-mpOQJJxpZfGl5agQnT6Xuf4-KHc ``` --- ## Example 3: Pagination ### Tool Call (using token from previous search) ```json { "query": "diabetes", "filter": "AREA[OverallStatus]RECRUITING AND AREA[Phase]PHASE3", "pageSize": 5, "pageToken": "ZVNj7o2Elu8o3lpiC82t5qr-mpOQJJxpZfGl5agQnT6Xuf4-KHc", "sort": "EnrollmentCount:desc" } ``` ### Tool Response ``` Found 5 studies (more pages available) • NCT05636176: A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation Status: RECRUITING • NCT05182970: Metformin and Prevention of Cardiovascular Events in Patients With Acute Myocardial Infarction and Prediabetes (MIMET) Status: RECRUITING • NCT07037459: Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity Status: RECRUITING • NCT07104500: VK2735 for Weight Management Phase 3 Status: RECRUITING • NCT07044297: A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011) Status: RECRUITING Next page token: ZVNj7o2Elu8o3lpiC82t5qr-mpOQJJxrZvil5agQlTmTv_w7IQ ``` --- ## Notes ### Query Parameter - Simple text search across study fields (conditions, interventions, sponsors, etc.) - Case-insensitive - Example: `"cancer immunotherapy"`, `"alzheimer"`, `"COVID-19 vaccine"` ### Filter Parameter - Advanced filtering using ClinicalTrials.gov filter syntax - Use `AREA[FieldName]Value` format - Combine filters with `AND` or `OR` - Common filters: - `AREA[OverallStatus]RECRUITING` - Only recruiting studies - `AREA[Phase]PHASE3` - Only Phase 3 trials - `AREA[StudyType]INTERVENTIONAL` - Only interventional studies - `AREA[LocationCountry]United States` - Studies in specific country ### Sort Parameter - Format: `FieldName:asc` or `FieldName:desc` - Common sort fields: - `EnrollmentCount` - Sort by number of participants - `LastUpdateDate` - Sort by most recently updated - `StartDate` - Sort by study start date ### Pagination - Default `pageSize`: 10 (maximum: 200) - Use `pageToken` from previous response to get next page - Tokens are temporary and specific to the search query ### Response Format - Displays NCT ID, title, and recruitment status - Shows total matching studies and if more pages are available - Provides pagination token for retrieving additional results